Intracameral versus intravitreal bevacizumab for neovascular glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional trial compares a single 1.25 mg/0.05 mL injection of bevacizumab delivered intracamerally versus intravitreally in adults with neovascular glaucoma and intraocular pressure above 21 mmHg who are candidates for trabeculectomy. Participants must have visible iris or angle neovascularization and at least hand-motion visual potential, and they will be followed with scheduled clinic visits for outcome assessment. Outcomes include intraocular pressure control, regression of neovascularization, need for additional glaucoma surgery, and ocular adverse events. The trial is conducted at the Glaucoma Unit, Department of Ophthalmology, Prince of Songkla University, with in-person follow-up required.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosis of neovascular glaucoma
2. The patients having IOP \> 21 mmHg, having the indication for trabeculectomy
3. The patients' age of at least 18-year-old
4. The patients having visual potential at least hand motion.
5. Present of NVI or NVA.
6. Willing and able to provide informed consent to participate in the study
7. Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits

Exclusion Criteria:

1. One eye patient
2. Patients having severe corneal edema or total hyphema obscure NVI or NVA view.
3. Cannot obtain endothelial cell count.
4. History of bevacizumab or fluorescence dye allergy.
5. Active infectious ocular disease including endophthalmitis and corneal ulcer
6. History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension
7. Has or planning to be pregnant or breastfeeding

Where it's running

• Glaucoma unit , Department of Ophthalmology Faculty of Medicine Prince of Songkla University
  Hat Yai, Changwat Songkhla, Thailand Recruiting

Study contacts

• Principal investigator: Assoc.Prof.Weerawat Kiddee, MD — Prince of Songkla University
• Study coordinator: Assoc.Prof.Weerawat Kiddee, MD
• Email: kweerawat@hotmail.com
• Phone: +66874954626

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.