Intra-operative intra-articular analgesic cocktail for patella fracture fixation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, double-blind, randomized controlled trial at Queen Mary Hospital compares patients who receive an intra-articular analgesic cocktail at the end of open reduction and internal fixation for patella fractures with those who do not. Participants are randomized 1:1 and both patients and outcome assessors are blinded to group allocation. Primary outcomes include postoperative pain relief and functional recovery; secondary outcomes include hospital length of stay and bed-stay related complications to estimate economic effects. The cocktail contains ketorolac, ropivacaine, triamcinolone, adrenaline and saline and is delivered intra-articularly after fixation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* acute patella fracture requiring open reduction and internal fixation;
* able to consent to surgery;
* pre-morbid able to ambulate

Exclusion Criteria:

* open fracture;
* polytrauma;
* previous knee arthroplasty;
* history of chronic pain,
* insulin-dependent diabetes mellitus, or peptic ulcer disease;
* chronic users of glucocorticoids, immunosuppressants, or immune-modulating agents, or of strong opioids (e.g.: morphine, fentanyl, hydromorphone, methadone, oxycodone, or meperidine);
* hepatitis B or C carrier;
* renal impairment (creatinine \[Cr\], \>200 mmol/L)

Where it's running

• Queen Mary Hospital, The University of Hong Kong
  Hong Kong, Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Christian Fang — Dept of Orthopaedics and Traumatology, Queen Mary Hospital
• Study coordinator: Christian FANG
• Email: cfang@hku.hk
• Phone: +852 22554581

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.