International registry for brain perforator aneurysms
The International PERForator ANeurysm Registry (PERFAN) - Natural History, Treatment, and Outcome of Intracranial Perforator Aneurysms
This study is creating a registry to collect information about rare brain aneurysms to see how different treatments work and improve care for people with these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 1 site (Bern) |
| Trial ID | NCT06189014 on ClinicalTrials.gov |
What this trial studies
This international, multicenter observational study aims to establish a registry to address the knowledge gap regarding lenticulostriate and basilar perforator aneurysms. It will collect data on the natural history, diagnostic evaluations, management strategies, and clinical outcomes of these rare aneurysms. The study will perform comparative analyses of treatment outcomes, including conservative, endovascular, and surgical approaches, while also evaluating factors such as aneurysm size and location. By gathering comprehensive data, the study seeks to enhance understanding and improve management of these conditions.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18 and older diagnosed with lenticulostriate or basilar perforator aneurysms.
Not a fit: Patients with aneurysms not classified as perforator aneurysms or those who refuse participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this registry could lead to improved treatment strategies and outcomes for patients with perforator aneurysms.
How similar studies have performed: While there is limited literature on perforator aneurysms, the establishment of registries for rare conditions has shown promise in enhancing understanding and treatment outcomes in other medical fields.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients from the Inselspital and from participating centers worldwide, who have been diagnosed or will be diagnosed with one or more lenticulostriate, basilar and/or other intracranial perforator aneurysms (starting from January 1st, 2013). * Patients aged ≥18 years * Written informed consent Exclusion Criteria: * Presence of documented written or verbal refusal. * Aneurysm arising from the middle cerebral artery trunk which does not incorporate a lenticulostriate artery (Vargas Type 1), as they are not perforator aneurysms by strict definition. * Aneurysm arising from the basilar artery trunk adjacent to a perforating branch but not involving a perforating artery (Satti Type 1), as they are not perforator aneurysms by strict definition.
Where this trial is running
Bern
- Institute of Diagnostic and Interventional Neuroradiology, Inselspital Bern — Bern, Switzerland (Recruiting)
Study contacts
- Principal investigator: Tomas Dobrocky, PD, MD — Institute of Diagnostic and Interventional Neuroradiology, Inselspital Bern
- Study coordinator: Tomas Dobrocky, PD, MD
- Email: perfan@insel.ch
- Phone: +41 31 63 2 68 81
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.