Internal jugular catheter placement and intracranial pressure measured by optic nerve sheath diameter
Evaluation of the Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Using Optic Nerve Sheath Diameter in Intubated Patients in the Intensive Care Unit
This test will see if placing an internal jugular vein catheter changes intracranial pressure, using optic nerve sheath diameter, in adults on mechanical ventilation in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cumhuriyet University Academic / other |
| Locations | 1 site (Sivas) |
| Trial ID | NCT07465419 on ClinicalTrials.gov |
What this trial studies
This observational study measures optic nerve sheath diameter (ONSD) by ultrasound before and after internal jugular vein catheterization in intubated ICU patients. Baseline ONSD is recorded in supine and 15° Trendelenburg positions, then measured immediately after catheter insertion in Trendelenburg and again at 5, 15, and 30 minutes after returning to supine. Measurements are taken transorbitally with a linear ultrasound probe, using the vertical diameter 3 mm behind the globe and averaging one reading from each eye. Patients with intracranial tumors, acute traumatic brain injury, eye disease, hypercarbia, inotropic support, or medications that affect intraocular pressure are excluded.
Who should consider this trial
Good fit: Adults over 18 who are mechanically ventilated in the intensive care unit and who do not have intracranial tumors, acute traumatic brain injury, eye disease, hypercarbia, inotropic support, or medications affecting intraocular pressure.
Not a fit: Patients with acute brain injury, intracranial tumors, significant eye disease, uncontrolled hypercarbia, or those receiving inotropes or IOP-altering drugs are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this could clarify whether internal jugular catheterization causes short-term increases in intracranial pressure and help guide safer line placement in ventilated ICU patients.
How similar studies have performed: Prior research supports that ONSD correlates with intracranial pressure and small studies have suggested central venous catheter placement can cause transient ICP rises, but results across studies are not definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The study will include adult patients over 18 years of age who are on mechanical ventilation support and monitored in the intensive care unit. Exclusion Criteria: * patients with intracranial tumors * patients with acute traumatic brain injury * patients diagnosed with acute or chronic eye diseases * hypercarbic patients * Patients receiving inotropic support * patients using medications that affect intraocular pressure
Where this trial is running
Sivas
- Sivas Cumhuriyet University — Sivas, Turkey (Türkiye) (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.