Intermittent fasting around chemotherapy for lymphoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group trial will compare a fasting approach added to standard chemotherapy against standard treatment alone in adults with diffuse large B-cell lymphoma or Hodgkin lymphoma. Participants in the fasting group will fast for 24 hours before and after each chemotherapy session and complete dietary diaries around treatment and for three days afterward. The study aims to assess safety, feasibility, and acceptability, along with patient-reported outcomes on health status and quality of life and documentation of chemotherapy-related adverse events. The trial is led by the University of Oslo with collaboration from several Oslo-area hospitals, and will recruit patients who are undergoing standard regimens such as R-CHOP or ABVD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with diffuse large B-cell lymphoma planned to receive R-CHOP (rituximab, vincristine, doxorubicin, cyclophosphamide, and prednisolone) and Hodgkin lymphoma receiving ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine)
* Age ≥ 18 years
* ECOG status 0-2
* Normal weight and overweight (BMI ≥ 18,5 kg/m\^2)

Exclusion Criteria:

* Receiving concurrent radiation therapy and/or treatment
* Other concomitant disease that may make intermittent fasting complicated such as diabetes mellitus
* ECOG status: \> 3
* BMI \< 18,5 kg/m2
* Age \> 80 years

Where it's running

• Department of Nutrition, University of Oslo
  Oslo, Oslo, Norway Recruiting

Study contacts

• Principal investigator: Sonja Brunvoll, PhD — Department of Nutrition, University of Oslo
• Study coordinator: Sonja Brunvoll, PhD
• Email: s.h.brunvoll@medisin.uio.no
• Phone: +4792087911

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.