Intensive statin therapy for ischemic stroke with intracranial atherosclerotic plaques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of intensive statin therapy on patients who have experienced an ischemic stroke due to intracranial atherosclerotic plaques. The study aims to determine how different intensities and durations of statin treatment influence the burden and composition of these plaques, which are assessed using high-resolution magnetic resonance imaging (HRMRI). By focusing on a population in Asia, the trial seeks to fill the gap in existing research that primarily addresses extracranial carotid plaques in Euro-American populations. The goal is to provide direct evidence on the efficacy of statins in stabilizing or reversing intracranial plaque progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient age between 18-80 years
2. Time of onset: within 1 week
3. NIHSS score ≤12
4. Acute ischemic stroke confirmed by head CT or MRI
5. Premorbid mRS ≤1
6. The degree of stenosis of carotid artery, vertebral artery and intracranial portion of internal carotid artery on the lesion side \<50%
7. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
8. Signed informed consent

Exclusion Criteria:

1. Intracranial hemorrhage found by head CT
2. Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart disease, aortic arch atherosclerosis)
3. Severe hepatic or renal dysfunction
4. Pregnant females
5. Abnormal elevation of creatine phosphokinase
6. Expected stent angioplasty
7. Blood sugar is out of control
8. Receiving statins within 1 month before onset
9. Obstinate hypertension with more than 140/90 mmHg after medication
10. Not willing and able to comply with scheduled visits, lifestyle guidelines, treatment plan, laboratory tests, and other study procedures
11. Unsuitable for this clinical studies assessed by researcher

Where it's running

• General Hospital of ShenYang Military Region
  Shenyang, China Recruiting

Study contacts

• Study coordinator: Xinhong Wang, Doctor
• Email: 450341972@qq.com
• Phone: 15309885658

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.