Intensive rehabilitation for children with polyhandicap

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effects of intensive psychomotor rehabilitation against standard care on the adaptive behavior of children with polyhandicap over a 12-month period. It evaluates various outcomes, including adaptive behavior, cognitive-motor skills, pain levels, and quality of life for both patients and their families. The study also assesses the tolerance of the intensive rehabilitation approach and the correlation between different evaluation scales. The goal is to determine the effectiveness of intensive rehabilitation in improving the lives of affected children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children between 4 and 13 years;
* With polyhandicap defined by association of the 5 following criteria:

  * Causal brain injury occurred before the age of 3 years
  * Severe or deep mental deficiency as defined by IQ \< 40, or no evaluable by the psychometric tests
  * Motor impairment: para / tetraparesis, hemiparesis, ataxia, or extrapyramidal motor disorders
  * Score of Gross Motor Function Classification System \[Palisano 1997\] is III, IV or V
  * Score of Functional Independence Measure \< 50;
* Hospitalization in a clinical setting participating to the study;
* Beneficiary of a social protection;
* Written consent signed by personnel holding parental authority or legal representative.

Exclusion Criteria:

* Patient with progressive encephalopathies including metabolic origin, epileptic, or neurodegenerative diseases;
* Planned to move in another clinical setting;
* Foreseeable difficulty in the following up in the study.

Where it's running

• Hôpital San Salvadour
  Hyères, Var, France Recruiting

Study contacts

• Principal investigator: Marie-Christine ROUSSEAU, MD — Polyhandicap adultes San Salvadour, APHP
• Study coordinator: Marie-Christine ROUSSEAU, MD
• Email: marie-Christine.rousseau@aphp.fr
• Phone: +33 (4) 94 38 08 17

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• New Eyes: Expanding the EVAL-PLH Polyhandicap Cohort

  This observational cohort study tests whether widening participation in the EVAL-PLH Polyhandicap cohort can make findings more representative for people with profound intellectual and multiple disabilities.

  Recruiting at 5 sites Assistance Publique Hopitaux De Marseille · Hendaye and 5 other locations · NCT06811441

• Diffusion MRI to map nerve lesions in obstetric brachial plexus palsy

  This study tests diffusion MRI and tractography to better understand nerve injuries in people with obstetric brachial plexus palsy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07767708

• Long-term心理 and cognitive check after stem cell transplant for immune deficiencies

  This study tests the long-term neurocognitive and psychological functioning of 6–8 year-old children who had an allogeneic stem cell transplant for a primary immune deficiency, at least two years after the transplant.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07766304

• Benchmarking AI language models against tumor boards for oncology treatment decisions

  This project tests whether frontier AI language models can match the treatment recommendations of multidisciplinary tumor boards for common cancers using standardized synthetic cases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt and 4 other locations · NCT07739121

• Gut microbes and autoinflammatory diseases: how they may be linked

  This study tests whether gut bacteria and their byproducts relate to digestive and inflammatory symptoms in people with autoinflammatory diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07718555

• How Eye Dominance Affects Fusion in Healthy Adults

  This study tests whether fusional vergence measurements differ when tested on the dominant eye versus the non-dominant eye in healthy adults.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07697131

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.