Instant messaging therapy for depression after stroke

Instant Message-delivered Brief Internet-based Cognitive Behavioural Therapy (iCBT) for Post-stroke Depression: a Mixed Method Study

Not applicable Interventional The University of Hong Kong · NCT05892965

This study tests if instant messaging therapy can help stroke survivors with depression feel better and improve their overall mental health.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment160 (estimated)
Ages18 Years and up
SexAll
SponsorThe University of Hong Kong Academic / other
Locations7 sites (Hong Kong and 6 other locations)
Trial IDNCT05892965 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of internet-based cognitive behavioral therapy (iCBT) delivered through instant messaging for individuals experiencing post-stroke depression. It targets stroke survivors who are within one year of their stroke event and have mild to moderately severe depressive symptoms. The intervention is personalized and guided by therapists, aiming to improve mental health outcomes in a population that often goes untreated. The study will assess the impact of this innovative approach on reducing depressive symptoms and enhancing overall well-being.

Who should consider this trial

Good fit: Ideal candidates for this study are stroke survivors aged 18 and older who can communicate in Chinese and use smartphone messaging functions.

Not a fit: Patients with severe depressive symptoms or those currently receiving other psychological interventions may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve mental health outcomes for stroke survivors suffering from depression.

How similar studies have performed: Previous studies have shown that internet-based cognitive behavioral therapy can effectively reduce depressive symptoms, indicating potential success for this novel application in post-stroke patients.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of stroke (ICD-10 codes: I60-I69);
* Aged ≥18;
* Able to read and communicate in Chinese (Cantonese or Putonghua);
* Able to use the text or voice messaging function on smartphone;
* MoCA 5-minute Protocol (cognitive screen) ≥14;
* Community-dwelling
* Less than 1 year after stroke event;
* PHQ-9 (depressive symptom) score ranging from 5 to 19 (note. mild: 5-9, moderate: 10-14, moderately severe: 15-19 and severe: 20-27)

Exclusion Criteria:

* Diagnosis of psychiatric disease before stroke event or currently taking psychotropic drug including antidepressants
* PHQ-9 ≥ 20 (i.e., severe depressive symptom)
* Currently participating in any type of psychological intervention

Where this trial is running

Hong Kong and 6 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions StrokeDepressive SymptomsMobile Phone Use
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.