Inspiratory muscle training for exercise-induced bronchoconstriction and cycling performance
Effect of Flow-Resistive Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Cycling Time-Trial Performance
This study is testing if a special breathing exercise can help people with exercise-induced bronchoconstriction and asthma breathe better and perform better while cycling.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Bloomington, Indiana) |
| Trial ID | NCT06336681 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effects of flow-resistive inspiratory muscle training (IMT) on individuals with exercise-induced bronchoconstriction (EIB) and asthma. It will assess various outcomes including EIB severity, symptoms, medication use, lung function, and cycling performance over an eight-week training period. Participants will engage in constant-load cycling exercises while their respiratory and limb muscle deoxygenation will be monitored. The hypothesis is that IMT will lead to improvements in EIB symptoms and overall cycling performance.
Who should consider this trial
Good fit: Ideal candidates are competitive recreational or college athletes aged 18 to 35 with mild to moderate asthma or EIB.
Not a fit: Patients with a history of smoking, cardiovascular, neurological, or metabolic diseases, or those currently on asthma maintenance medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance exercise tolerance and quality of life for patients with exercise-induced bronchoconstriction.
How similar studies have performed: While there is limited data specifically on IMT for EIB, previous studies have shown positive outcomes of IMT on asthma symptoms and inspiratory muscle strength.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female, between the ages of 18 to 35 years. * Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience. * Body Mass Index (BMI) of 18.5 to 28 kg/m\^2 * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ). * Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) \> 65% of predicted. * A ≥ 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH). * Prescribed short-acting β2-agonists (SABAs) by a physician. * Comfortable not taking SABA before experimental visits. Exclusion Criteria: * History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease. * Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers) * Any injuries in the past 6 months. * Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.). * Has had or is positive for COVID-19. * Resting blood pressure of \> 130 mmHg systolic or 90 mmHg diastolic. * Resting Pulse rate of \> 100 bpm. * Regularly consuming fish oil supplements or eating more then one fish meal per week
Where this trial is running
Bloomington, Indiana
- School of Public Health-Bloomington — Bloomington, Indiana, United States (Recruiting)
Study contacts
- Principal investigator: Tim Mickleborough, Ph.D. — Indiana University
- Study coordinator: Tim Mickleborough, Ph.D.
- Email: tmickleb@indiana.edu
- Phone: (812) 855-0753
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.