Inspiratory muscle training for adolescents with Familial Mediterranean Fever
Outcomes of Inspiratory Muscle Training in FMF Adolescents
This trial will try a daily inspiratory muscle training program to see if it improves breathing strength, exercise tolerance, and fatigue in teenagers (ages 13–17) with Familial Mediterranean Fever who are taking colchicine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 13 Years to 17 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Giza, Dokki) |
| Trial ID | NCT07129538 on ClinicalTrials.gov |
What this trial studies
Adolescents with Familial Mediterranean Fever will be assigned to an inspiratory muscle retraining (IMR) group or a waitlist control, with 20 participants per group. The IMR group will perform two IMR sessions daily, five days per week, for eight weeks; each session consists of three sets of ten breathing cycles. Both groups will continue their prescribed colchicine treatment during the study. Outcomes will focus on changes in pulmonary function, exercise tolerance, and fatigue.
Who should consider this trial
Good fit: Teenagers aged 13–17 with a confirmed diagnosis of Familial Mediterranean Fever who are medically stable and taking colchicine, and who do not have the listed exclusion conditions, are ideal candidates.
Not a fit: Patients with significant cardiac, renal, liver, diabetes, or neurological disorders, those outside the 13–17 age range, or those unable to perform the breathing exercises are unlikely to receive benefit from this protocol.
Why it matters
Potential benefit: If successful, the program could strengthen breathing muscles and improve exercise capacity and fatigue in adolescents with FMF.
How similar studies have performed: Inspiratory muscle training has shown benefits for respiratory muscle strength and exercise capacity in other respiratory and neuromuscular conditions, but its effects specifically in FMF adolescents are not well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * FMF adolecents * ages 13 -17 years * forty patients Exclusion Criteria: * cardiac problems * renal problems * liver problems * diabetes * brain problems
Where this trial is running
Giza, Dokki
- Faculty of physical therapy — Giza, Dokki, Egypt (Recruiting)
Study contacts
- Principal investigator: Ali MA Ismail, lecturer — Cairo University
- Study coordinator: Ali MA Ismail, lecturer
- Email: ali.mohamed@pt.cu.edu.eg
- Phone: 01005154209
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.