Innovative methods for preserving women's fertility through ovarian tissue cryopreservation
Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation
This study is testing different types of freezing containers to see which one keeps ovarian tissue healthier for women who want to preserve their fertility.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 37 Years |
| Sex | Female |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Trial ID | NCT06724471 on ClinicalTrials.gov |
What this trial studies
This project evaluates the impact of different cryogenic tube types on the quality and functionality of ovarian tissue after cryopreservation. It involves optimizing freezing and thawing protocols using a differential scanning calorimeter to analyze the thermodynamic properties of the freezing medium. The study will utilize human ovarian cortex samples from women undergoing benign cyst resection, comparing the outcomes of tissue preserved in thermosoldered versus screw cap cryogenic tubes. Key assessments will include follicle density, morphology, and the balance of proliferation and apoptosis in the ovarian tissue.
Who should consider this trial
Good fit: Ideal candidates are adult women aged 18 to 37 scheduled for benign ovarian cyst resection.
Not a fit: Patients with conditions such as polycystic ovary syndrome, diminished ovarian reserve, severe endometriosis, or malignant cysts may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of fertility preservation methods for women undergoing cancer treatment.
How similar studies have performed: While ovarian tissue cryopreservation has been performed previously, this study's focus on comparing cryogenic tube types is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult woman scheduled for benign ovarian cyst resection (dermoid, functional, mucinous or serous cysts) * Below 37 years old and above 18 years old * Capable of giving written informed consent to participate in the research study * Affiliated to social welfare service Exclusion Criteria: * Women above 37 years old and below 18 years old * Polycystic ovary syndrome * Diminished ovarian reserve * Severe endometriosis * Malignant and endometrial cysts
Where this trial is running
Clermont-Ferrand
- University Hospital — Clermont-Ferrand, France (Recruiting)
Study contacts
- Principal investigator: Florence Brugnon, MD, PhD — University Hospital, Clermont-Ferrand
- Study coordinator: Gaelle Marteil, PhD
- Email: gaelle.marteil@uca.fr
- Phone: +334 73 17 80 81
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.