Injection of mashed parathyroid tissue into the forearm during thyroid surgery to prevent long-term parathyroid failure
Official title: Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoperative Parathyroid Insufficiency (IMIPAT Study) - a Prospective Multicentre Trial
Run by Medical University of Vienna · NCT07516990 · Data updated 2026-11-12
This trial will try injecting mashed parathyroid tissue into a forearm muscle during thyroid surgery to help adults avoid permanent low parathyroid function after their operation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 2 sites (Vienna, State of Vienna and 1 other locations) |
| Status | Recruiting |
| Started | April 2, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07516990 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) undergoing thyroid surgery in which parathyroid autotransplantation into the forearm is performed and who provide informed consent are the intended participants.
✕Probably not a fit
Patients under 18, those with hyperparathyroidism, or those who do not receive a parathyroid autotransplantation during their operation are not expected to benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
During thyroidectomy, devascularized parathyroid glands are commonly re-implanted to restore hormone production; this trial uses intramuscular injection of finely mashed parathyroid tissue into the brachioradialis muscle as the implantation method. The technique is intended to allow diffusion-based nutrition until the grafts revascularize and begin producing parathyroid hormone. Eligible adult patients who undergo parathyroid autotransplantation during their thyroid operation at the enrolling centers will receive the injection and be followed for graft function. The protocol builds on prior reports of successful forearm autografts and aims to compare the practicality and graft viability of the injection approach in routine thyroid surgery.
Why it matters
Potential benefit: If successful, the technique could lower the risk of permanent hypoparathyroidism and reduce the need for lifelong calcium and vitamin D replacement.
How similar studies have gone: Related implantation and injection techniques have shown favorable graft function and measurable PTH gradients in patients (including those with renal hyperparathyroidism), but optimal methods remain debated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * signed informed consent * parathyroid autotransplantation in forearm performed during thyroid surgery * 18 years of age and above Exclusion Criteria: * under 18 years of age * informed consent not signed * hyperparathyroidism * no parathyroid autotransplantation performed
Where it's running
-
Wiener Gesundheitsverbund, Klinik Landstrasse
Vienna, State of Vienna, Austria Recruiting -
Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna
Vienna, State of Vienna, Austria Recruiting
Study contacts
- Principal investigator: Lindsay Hargitai, Dr. — Medical University of Vienna
- Study coordinator: Lindsay Hargitai, Dr.
- Email: lindsay.hargitai@meduniwien.ac.at
- Phone: +43 (0)1 40400-56210
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.