Injection of extracellular vesicles for knee osteoarthrosis treatment
Official title: Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Extracellular Vesicles (EV) for Advanced Stage III and IV KOA
Run by University of Jordan · NCT06937528 · Data updated 2026-11-12
This study is testing whether injecting tiny particles called extracellular vesicles can help people with knee osteoarthritis feel better.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 42 Years to 75 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Jordan Academic / other |
| Locations | 1 site (Amman) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | January 30, 2026 |
| Study ends | January 30, 2027 |
| Registry record updated | April 22, 2025 |
| Trial ID | NCT06937528 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with severe knee osteoarthrosis at stage III or IV.
✕Probably not a fit
Patients with significant knee joint subluxation, those on anticoagulant therapy, or individuals with uncontrolled comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial involves injecting extracellular vesicles (EV) into patients diagnosed with knee osteoarthrosis. A total of 50 patients, both male and female, will be enrolled based on strict inclusion and exclusion criteria. Following the injection, participants will undergo clinical assessments, laboratory investigations, and magnetic resonance imaging (MRI) of the treated knee to evaluate the effects of the treatment.
Why it matters
Potential benefit: If successful, this treatment could provide a novel therapeutic option for patients suffering from knee osteoarthrosis.
How similar studies have gone: While the use of extracellular vesicles is a novel approach in this context, similar studies have shown promise in other applications, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Severe KOA stage III or IV by Laurance \& Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint. * Willing to participate by signing the informed consent Exclusion Criteria: * Sublaxation beyond 20 degrees of the bones of the knee joint * Oral anticoagulants or heparin therapy * Heart failure or arrhythmia * Body Mass Index \> 35 * Uncontrolled Diabetes Mellitus. * Evidence of Infectious Diseases. * Active infection * Malignancy * Pregnancy * Anemia less than 11g/dl or thrombocytopenia less than 100,000 or leucopenia less than 3000. * Unreliable patients * Non-resident in Jordan
Where it's running
-
Cell Therapy Center
Amman, Jordan Recruiting
Study contacts
- Study coordinator: Hanan Jafar, PhD
- Email: hanan.jafar@gmail.com
- Phone: 00962798871087
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating the GEMINI SL Knee Prosthesis for Osteoarthrosis
This study is testing how well the GEMINI SL knee prosthesis works and stays safe for people with osteoarthrosis over a 10-year period.
-
Evaluating long-term outcomes of hip replacement surgeries
This study is trying to see how well Corin hip replacement devices work and how safe they are for people getting hip surgery over the long term.
-
Registry for Basal Joint Arthritis Treatments
This study is collecting information to see which treatments work best for people with thumb arthritis, helping to find the most effective ways to relieve pain and improve function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.