Injectable platelet-rich fibrin for improving soft tissue around dental implants
Official title: Evaluation of the Effect of Injectable Platelet-Rich Fibrin on Peri-Implant Soft Tissue Phenotype
Run by Kutahya Health Sciences University · NCT06753396 · Data updated 2026-11-12
This study is testing if an injectable treatment made from platelets can help improve the soft tissue around dental implants for people who have thin gums.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Kutahya Health Sciences University Academic / other |
| Locations | 1 site (Kütahya) |
| Status | Recruiting |
| Started | December 15, 2022 |
| Main results expected | December 15, 2025 |
| Study ends | April 15, 2026 |
| Registry record updated | September 11, 2025 |
| Trial ID | NCT06753396 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are systemically healthy, non-smoking adults over 18 with inadequate peri-implant keratinized mucosa and mucosal thickness.
✕Probably not a fit
Patients with adequate peri-implant keratinized mucosa and mucosal thickness, or those with systemic diseases or smoking habits that exceed 10 cigarettes per day, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effects of injectable platelet-rich fibrin on peri-implant soft tissue in patients with insufficient keratinized mucosa. It aims to assess how this treatment can enhance mucosal thickness and width, potentially improving implant health and aesthetics. The study will involve 80 healthy, non-smoking participants over 18 years old, who will receive subgingival and submucosal applications of the fibrin. The methodology focuses on a non-invasive approach to enhance soft tissue phenotype around dental implants.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the health and longevity of dental implants by enhancing the surrounding soft tissue.
How similar studies have gone: While injectable platelet-rich fibrin has been studied in other contexts, its application specifically around dental implants is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. be over 18 years old 2. The patient does not have any systemic disease 3. Patients who do not smoke or who smoke less than 10 cigarettes 4. Peri-implant keratinized mucosa width less than 2 mm 5. Peri-implant mucosal thickness less than 2 mm Exclusion Criteria: 1. Being out of the defined age group 2. Any systematic contraindication for periodontal surgery 3. Patients who smoke more than 10 cigarettes per day 4. Patients with adequate peri-implant keratinized mucosa width and mucosal thickness 5. Pregnancy 6. Patients taking medication that suppresses the immune system or impairs healing 7. Patients taking medication that impairs the bleeding condition
Where it's running
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Kütahya Health Sciences University Faculty of Dentistry
Kütahya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Berceste Güler Ayyıldız
- Email: berceste.guler@ksbu.edu.tr
- Phone: +05059359207
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.