Injectable platelet-rich fibrin for improving soft tissue around dental implants
Evaluation of the Effect of Injectable Platelet-Rich Fibrin on Peri-Implant Soft Tissue Phenotype
This study is testing if an injectable treatment made from platelets can help improve the soft tissue around dental implants for people who have thin gums.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kutahya Health Sciences University Academic / other |
| Locations | 1 site (Kütahya) |
| Trial ID | NCT06753396 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of injectable platelet-rich fibrin on peri-implant soft tissue in patients with insufficient keratinized mucosa. It aims to assess how this treatment can enhance mucosal thickness and width, potentially improving implant health and aesthetics. The study will involve 80 healthy, non-smoking participants over 18 years old, who will receive subgingival and submucosal applications of the fibrin. The methodology focuses on a non-invasive approach to enhance soft tissue phenotype around dental implants.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy, non-smoking adults over 18 with inadequate peri-implant keratinized mucosa and mucosal thickness.
Not a fit: Patients with adequate peri-implant keratinized mucosa and mucosal thickness, or those with systemic diseases or smoking habits that exceed 10 cigarettes per day, may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the health and longevity of dental implants by enhancing the surrounding soft tissue.
How similar studies have performed: While injectable platelet-rich fibrin has been studied in other contexts, its application specifically around dental implants is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. be over 18 years old 2. The patient does not have any systemic disease 3. Patients who do not smoke or who smoke less than 10 cigarettes 4. Peri-implant keratinized mucosa width less than 2 mm 5. Peri-implant mucosal thickness less than 2 mm Exclusion Criteria: 1. Being out of the defined age group 2. Any systematic contraindication for periodontal surgery 3. Patients who smoke more than 10 cigarettes per day 4. Patients with adequate peri-implant keratinized mucosa width and mucosal thickness 5. Pregnancy 6. Patients taking medication that suppresses the immune system or impairs healing 7. Patients taking medication that impairs the bleeding condition
Where this trial is running
Kütahya
- Kütahya Health Sciences University Faculty of Dentistry — Kütahya, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Berceste Güler Ayyıldız
- Email: berceste.guler@ksbu.edu.tr
- Phone: +05059359207
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.