Injectable Platelet-Rich Fibrin and Microneedling for Gum Reconstruction
Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone (A Case Series )
This study is testing if using a special injection along with microneedling can help people with gum recession rebuild their gum tissue better than standard treatments.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06021301 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the use of injectable platelet-rich fibrin (iPRF) combined with microneedling to reconstruct interdental papillae in patients with recession. Participants will undergo a series of treatments involving microneedling followed by iPRF injections to enhance wound healing and tissue regeneration. The study aims to evaluate the effectiveness of this non-surgical approach compared to traditional methods, focusing on long-term maintenance of papillary regeneration. Patients will be monitored for clinical outcomes and tissue measurements over a period of six months.
Who should consider this trial
Good fit: Ideal candidates are nonsmoking adults over 18 with specific types of interdental papilla recession and good oral hygiene.
Not a fit: Patients with systemic diseases, active periodontal diseases, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive and more effective solution for patients suffering from gum recession.
How similar studies have performed: While the combination of iPRF and microneedling is promising, it represents a novel approach with limited prior studies demonstrating its effectiveness in this specific application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nonsmoking patients aged above 18 years. * At least one site with interdental papilla recession in the anterior region of the maxillary or mandibular jaws. * The distance from the contact point to alveolar bone is crest \< 7 mm. * Class I or Class II papillary recession, according to Nordland and Tarnow's classification systems (Nordland et al., 1998). * No active periodontal diseases and good oral hygiene. Exclusion Criteria: * Patients were excluded from the study if they have: * Spacing or crowding between the teeth to be treated * Abnormal tooth shape * Systemic diseases such as diabetes mellitus, hypertension or conditions that alter the outcome of periodontal therapy. * In addition, patients will be excluded if they are Pregnant and lactating women.
Where this trial is running
Cairo
- Faculty of Dentistry ,Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: yasmeen tolba, Resident — department of periodontology ,cairo university
- Study coordinator: yasmeen tolba, Resident
- Email: yasmeen.tolba@dentistry.cu.edu.eg
- Phone: 01027453609
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.