Injectable hyaluronic acid to improve bone healing after lower wisdom-tooth extraction
Official title: Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
Run by Jordan University of Science and Technology · NCT07318298 · Data updated 2026-11-12
This trial will try placing a hyaluronic acid gel in one socket after removing a lower wisdom tooth to see if it reduces pain and helps the bone heal in adults having both lower wisdom teeth removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Jordan University of Science and Technology Academic / other |
| Locations | 1 site (Irbid) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | February 26, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | January 28, 2026 |
| Trial ID | NCT07318298 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–35 with bilateral impacted mandibular third molars (Pell and Gregory Class II, Position B), ASA Physical Status I, who can consent and attend follow‑up visits are the ideal candidates.
✕Probably not a fit
Patients with systemic diseases (e.g., diabetes, hypertension), active local infection, recent anti‑inflammatory use, pregnancy or breastfeeding, or cognitive/motor impairments are unlikely to be eligible or to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, controlled split-mouth trial at Jordan University of Science and Technology enrolling 20 adults aged 18–35 who require bilateral impacted mandibular third molar removal. In each patient one extraction socket will be randomly treated with low‑molecular‑weight sodium hyaluronate gel (Hyadent®) plus a collagen sponge while the contralateral socket receives a collagen sponge alone. All procedures are performed by a single operator and randomization uses sealed envelopes; outcomes include postoperative pain and alveolar socket bone healing assessed clinically and radiographically, with bone biopsy noted as an intervention. Comparing paired sockets within the same patient reduces individual variability in healing responses.
Why it matters
Potential benefit: If successful, topical hyaluronic acid could reduce postoperative pain and accelerate bone healing after wisdom‑tooth removal.
How similar studies have gone: Hyaluronic acid has documented anti‑inflammatory and regenerative effects and smaller dental studies have suggested improvements in soft‑tissue healing, but robust randomized evidence specifically showing improved socket bone healing is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Male and female participants aged 18 to 35 years Presence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B Classified as American Society of Anesthesiologists (ASA) Physical Status I Absence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia) Ability to maintain adequate oral hygiene Ability to understand and provide written informed consent Ability to read and understand Arabic or English Willingness to comply with study procedures and follow-up visits Exclusion Criteria: History of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions Presence of severe or chronic illness requiring frequent hospitalization Pregnant or breastfeeding individuals History of cognitive or motor impairment that may interfere with study participation Use of anti-inflammatory or analgesic medications within two weeks before surgery Known allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) Current smoker Use of anticoagulant therapy Any condition that, in the investigator's judgment, may interfere with healing or study outcomes
Where it's running
-
Higher specialty training center
Irbid, Jordan Recruiting
Study contacts
- Study coordinator: Tamimi
- Email: zztamimi@just.edu.jo
- Phone: 00962795036670
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.