Inhaled anesthetics versus dexmedetomidine for maintaining general anesthesia
Official title: Beyond Inhalational Agents: Dexmedetomidine for Maintenance of General Anesthesia - A Prospective Randomized Clinical Trial
Run by Bakirkoy Dr. Sadi Konuk Research and Training Hospital · NCT07363681 · Data updated 2026-11-12
This test compares dexmedetomidine plus remifentanil with desflurane plus remifentanil for adults over 39 having elective endoscopic urologic surgery to see which gives more stable anesthesia and faster recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 39 Years to 99 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Bakirkoy Dr. Sadi Konuk Research and Training Hospital Government |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | February 1, 2026 |
| Study ends | March 9, 2026 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT07363681 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 39 or older with ASA physical status II–IV who can provide informed consent and are scheduled for elective endoscopic urologic procedures such as URS, TUR-B, PCNL, or TUR-P.
✕Probably not a fit
Patients with neuropsychiatric disorders, a history of substance abuse, current psychoactive medication use, those who require conversion to open surgery, younger than 39, or undergoing emergency procedures are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized prospective study enrolled 150 patients aged 39 and older scheduled for elective endoscopic urological procedures at Bakırköy Dr. Sadi Konuk Training and Research Hospital in Istanbul. Patients were randomized to receive either dexmedetomidine with remifentanil or desflurane with remifentanil for maintenance of general anesthesia. Intraoperative monitoring recorded anesthesia depth and hemodynamic parameters continuously, and postoperative outcomes included VAS pain scores, RASS agitation-sedation, and modified Aldrete recovery scores as well as the postoperative ward destination. The protocol aimed to compare intraoperative stability, recovery profiles, and potential environmental advantages of a fully metabolized maintenance agent versus inhaled anesthetics.
Why it matters
Potential benefit: If successful, using dexmedetomidine for maintenance could produce more stable blood pressure and heart rate during surgery, speed recovery in the PACU, and reduce environmentally harmful anesthetic emissions.
How similar studies have gone: Previous studies have shown that adding intraoperative dexmedetomidine to inhaled anesthetics can improve hemodynamic stability and shorten recovery, but replacing inhaled agents entirely with dexmedetomidine for maintenance is less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Age ≥ 39 years * Classified as ASA physical status II-IV * Scheduled for elective endoscopic urological surgery (e.g., URS, TUR-B, PCNL, TUR-P) * Scheduled for postoperative follow-up in the Post-Anesthesia Care Unit (PACU) * Ability to provide written informed consent Exclusion Criteria * Requirement for conversion to open surgery during the perioperative period * Patients who decline to participate in the study * Presence of neuropsychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, or history of head trauma) * History of alcohol or substance abuse * Use of psychoactive medications * Inability to communicate adequately for any reason
Where it's running
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Bakirkoy dr. Sadi Konuk
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Nalan Saygi̇ Emi̇r
- Email: nasaemir@hotmail.com
- Phone: 00905422363672
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.