Inhaled acetylcysteine to prevent pneumonia in adults on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Critically ill adults who are intubated and expected to need mechanical ventilation for more than 48 hours will receive inhaled acetylcysteine or inhaled normal saline while in the ICU. The trial monitors whether acetylcysteine changes the incidence of ventilator-associated pneumonia and the time until pneumonia develops. Key exclusions include patients already on long-term NAC, those who are pregnant, immunocompromised, brain dead, or hemodynamically unstable. Outcomes include infection rates and timing of ventilator-associated complications during the ICU stay.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18-64 years, either male or female.
2. Critically ill patients who have undergone intubation and are on mechanical ventilation.
3. Expected duration of mechanical ventilation of more than 48 hours.
4. Provided consent to participate in this clinical trial by next of kin.

Exclusion Criteria:

1. Patients currently on long-term NAC treatment.
2. Confirmed brain death.
3. Recent chest infection.
4. Immunocompromised patients on immunosuppressive medication.
5. Patients mechanically ventilated in another hospital.
6. Pregnant women.
7. Mean arterial pressure (MAP) \<60 mmHg despite adequate resuscitation and vasopressor therapy at the time of randomization.
8. Known intolerance or hypersensitivity to study medication.
9. Presence of a condition or abnormality that would compromise the quality of the data.

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Where it's running

• Cairo University Hospitals
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Maggie M Abbassi, professor of clinical pharmacy
• Email: Maggie.abbassi@pharma.cu.edu.eg
• Phone: 00201001589925

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.