Inhalation of hypertonic saline before physiotherapy for bronchiectasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of inhaling hypertonic saline solution prior to the ELTGOL physiotherapy technique in adults with bronchiectasis. The study aims to determine if this combination can enhance mucus clearance, improve mucus properties, and ultimately lead to better disease management. It is a 12-month, multicenter, double-blind, randomized controlled trial where participants will be assigned to receive either hypertonic saline, isotonic saline, or no inhalation before physiotherapy. The primary focus is on evaluating the effectiveness of this approach in improving respiratory function and quality of life for patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with bronchiectasis confirmed by high resolution computed tomography
* No exacerbations in the previous month
* Chronic mucopurulent and purulent sputum
* ≥10ml daily expectoration
* At least one exacerbation in the previous year
* (Forced expiratory volume the 1st second) FEV1 ≥30% after bronchodilation
* Sign the informed consent

Exclusion Criteria:

* Current smokers or a smoking history of ≥20 p-y
* Asthma, allergic bronchopulmonary aspergillosis or Cystic Fibrosis
* Pregnant or lactating women
* Following mucoactive treatment in the previous month
* Inability to perform ELTGOL, spirometry or to attend visits
* Practicing pulmonary rehabilitation in the previous 6 months
* Change of treatment the previous month
* Uncontrolled hypertension

Where it's running

• University Hospital of Girona Dr. Josep Trueta
  Girona, Spain Recruiting

Study contacts

• Principal investigator: Montserrat Vendrell, PhD MD — University Hospital of Girona Dr. Josep Trueta
• Study coordinator: Gerard Muñoz, PhD PT
• Email: munoz.gerard@gmail.com
• Phone: 0034-972940294

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.