Infraclavicular axillary vein collapsibility to predict who will respond to fluids in sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness in Spontaneously Breathing Patients in Sepsis-related Acute Circulatory Failure: a Prospective Observational Study
This trial tests whether the infraclavicular axillary vein collapsibility index can tell which adults with sepsis who are breathing on their own will increase their blood flow after getting IV fluids.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07507877 on ClinicalTrials.gov |
What this trial studies
This observational study measures the infraclavicular axillary vein collapsibility index using ultrasound in spontaneously breathing adult patients with sepsis and clinical signs of acute circulatory failure. Investigators will compare the vein collapsibility measurements with patients' fluid responsiveness after fluid administration to determine predictive value. The protocol enrolls adults meeting at least two SIRS criteria and excludes mechanically ventilated patients and those under 18. The goal is to validate a noninvasive alternative to inferior vena cava measurements for guiding resuscitation decisions.
Who should consider this trial
Good fit: Ideal candidates are adults (≥18 years) with sepsis who are breathing without mechanical ventilation, meet at least two SIRS criteria, and show clinical signs of acute circulatory failure.
Not a fit: Mechanically ventilated patients, children under 18, or patients without sepsis-related circulatory failure are unlikely to benefit from this technique as studied here.
Why it matters
Potential benefit: If successful, this approach could help clinicians decide who needs IV fluids and avoid fluid overload by providing a noninvasive bedside predictor of fluid responsiveness.
How similar studies have performed: Previous work has established inferior vena cava collapsibility as a predictor of fluid responsiveness, and axillary or other peripheral venous collapsibility measures have shown promising but less well-validated results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients ≥18 years. * Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS). * Spontaneously breathing patients. * Clinical signs of acute circulatory failure. Exclusion Criteria: * Patients below the age of 18 years. * Mechanically ventilated patients
Where this trial is running
Cairo
- Ain-Shams University Hospitals — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ibrahim Mamdouh Esmat
- Email: ibrahim_mamdouh@med.asu.edu.eg
- Phone: 01001241928
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.