Infiltration of the phrenic nerve for chronic neck pain relief
Official title: Phrenic Afferences In Organic and Metabolic Illness: Central Sensitization
Run by University of Seville · NCT05605639 · Data updated 2026-11-12
This study is testing if injecting a pain-relieving medication into the phrenic nerve can help people with chronic neck pain feel better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Seville Academic / other |
| Locations | 2 sites (Dos Hermanas, Seville and 1 other locations) |
| Status | Recruiting |
| Started | November 17, 2022 |
| Main results expected | July 2025 |
| Study ends | July 2025 |
| Registry record updated | December 11, 2024 |
| Trial ID | NCT05605639 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 64 who experience chronic neck pain and have peridiaphragmatic visceral disorders.
✕Probably not a fit
Patients with neurological, traumatic, oncological, infectious, or rheumatic conditions will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of phrenic nerve infiltration using bupivacaine on patients suffering from chronic neck pain associated with peridiaphragmatic visceral disorders. The study aims to determine whether this intervention can reduce pain sensitivity and improve neck symptoms through a randomized controlled trial. Participants will be assessed for changes in pain threshold, visual analogue scale scores, range of motion, and craniocervical questionnaires. The trial focuses on individuals without specific neurological, traumatic, or infectious causes for their pain.
Why it matters
Potential benefit: If successful, this approach could provide significant relief for patients suffering from chronic neck pain by addressing underlying visceral issues.
How similar studies have gone: While the specific approach of phrenic nerve infiltration is novel, previous studies have indicated that addressing visceral pain sources can improve chronic pain conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over 18 and under 64 years old * Patients attending to the physician or physical therapist with a main complaint of neck pain * Presentation of any peridiaphragmatic visceral disorder. * That the subject agrees to participate in the project by signing the informed consent. Exclusion Criteria: * Illness of neurological, traumatic, oncological, infectious or rheumatic (fibromyalgia, ankylosing spondylitis...) origin. * Uncooperative subject. * Severe psychiatric illness. * Loss of Cognitive Ability. * Contraindication to infiltration of the phrenic nerve. * History of head, spinal or upper limb surgery * History of infiltration for the neck pain in the previous 3 months * History of physical therapy for the neck pain in the previous 30 days
Where it's running
-
Nacho Navarro Fisioterapia
Dos Hermanas, Seville, Spain Recruiting -
Crux Roxa
Seville, Spain Recruiting
Study contacts
- Principal investigator: Angel Oliva Pascual-Vaca, Dr — University of Seville
- Study coordinator: Angel Oliva Pascual-Vaca, Dr
- Email: angeloliva@us.es
- Phone: 0034 954486524
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.