Individually Tailored, Supervised, Remote Exercise to Improve Function in Stage I-III Gastroesophageal Cancer Survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study investigates a remote, tailored exercise program delivered with supervision for adults who have finished curative treatment for stage I-III gastroesophageal cancer. Feasibility is the primary aim, focusing on attendance and completion of assessments, with secondary goals including changes in physical function, frailty, cognitive function, anxiety, depression, sleep, and quality of life. The trial uses actigraphy, biospecimen collection, and electronic health record review alongside the exercise intervention. Outcomes will be measured from baseline to post-intervention to determine potential benefits and safety in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥ 18 years old at the start of study treatment
* Diagnosis of early-stage (Stage I, II, III) esophageal, gastroesophageal junction, or gastric cancer. Histology can be adenocarcinoma, squamous cell carcinoma, or poorly differentiated carcinoma
* Treated with at least one systemic therapy (chemotherapy or immunotherapy) and within 12 months of completing curative intent gastroesophageal cancer (GEC) treatment
* Have evidence of physical function impairment, defined as a SPPB score of \< 12) at baseline
* Ability to understand English and the willingness to sign a written informed consent document

Exclusion Criteria:

* Patients with stage I disease who underwent endoscopic resection or surgery alone without perioperative systemic therapy
* Patients with stage IV disease or unresectable locally advanced disease taking a palliative treatment approach without a clearly defined end of treatment
* Patients currently receiving ongoing systemic therapy for GEC or another malignancy
* Patients who are unable to provide informed consent
* Any other condition or pre-existing co-morbidity that would, in the Investigator's judgment, contraindicate the participation in the study due to safety concerns with study procedures
* Currently participating in another exercise intervention research study seeking to improve functional status, alleviate frailty, muscle strength, exhaustion/fatigue, or cognitive function

Where it's running

• UCLA / Jonsson Comprehensive Cancer Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Jingran Ji, MD — UCLA / Jonsson Comprehensive Cancer Center
• Study coordinator: Jingran Ji, MD
• Email: jingranji@mednet.ucla.edu
• Phone: 310-829-5471

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.