Individualized rTMS for improving motor recovery in stroke patients
Official title: Efficacy of Individualized Repetitive Transcranial Magnetic Stimulation Based on Cortical Laterality for Motor Recovery in Stroke Patients
Run by National Taiwan University Hospital · NCT05914038 · Data updated 2026-11-12
This study is testing if a personalized brain stimulation treatment can help stroke patients recover better and improve their movement within three months of their stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei County, Taipei) |
| Status | Recruiting |
| Started | October 13, 2023 |
| Main results expected | May 20, 2025 |
| Study ends | May 20, 2027 |
| Registry record updated | October 18, 2024 |
| Trial ID | NCT05914038 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 20 who have experienced a unilateral ischemic or hemorrhagic stroke within the last three months and have limited upper limb strength.
✕Probably not a fit
Patients with a history of previous strokes, significant neurological disorders, or contraindications to rTMS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of individualized repetitive transcranial magnetic stimulation (rTMS) tailored to the lateralization index in enhancing motor recovery and cortical excitability in patients who have experienced a stroke. The approach utilizes both high and low-frequency rTMS to modulate cerebral cortex excitability, with a focus on subacute stroke patients within three months of their event. Unlike previous studies that applied a uniform rTMS protocol, this study aims to personalize treatment based on individual patient characteristics. The goal is to determine if this tailored approach can lead to better recovery outcomes.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for motor recovery in stroke patients.
How similar studies have gone: While traditional rTMS has been studied in stroke rehabilitation, this individualized approach based on lateralization index is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Unilateral ischemic or hemorrhagic stroke 2. Stroke within 3 months 3. Medical Research Council Scale for Muscle Strength in upper limb ≤ 3 4. No previous stroke, seizure, dementia, Parkinson's disease or other degenerative neurological diseases. 5. Patient could sit over 15 minutes 6. Age over 20 Exclusion Criteria: 1. Previous stroke, traumatic brain injury, brain tumor 2. With central nervous system disease (spinal cord injury, Parkinson's disease) 3. Any contraindication to rTMS (seizure, alcoholism, metal implant, pacemaker) 4. Patients unable to cooperate the treatment 5. Pregnancy 6. Depression
Where it's running
-
National Taiwan University Hospital
Taipei County, Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Meng Ting Lin, M.D. — The Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital
- Study coordinator: Meng Ting Lin, M.D.
- Email: b96401093@ntu.edu.tw
- Phone: +886-2312-3456
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Using patterned non-invasive brain stimulation (iTBS) to improve hand strength after chronic stroke
This trial will test whether a high-dose patterned non-invasive brain stimulation (iTBS) can help people with chronic stroke regain hand muscle strength and motor control.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
-
Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.