Individualized rTMS for improving motor recovery in stroke patients
Efficacy of Individualized Repetitive Transcranial Magnetic Stimulation Based on Cortical Laterality for Motor Recovery in Stroke Patients
This study is testing if a personalized brain stimulation treatment can help stroke patients recover better and improve their movement within three months of their stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei County, Taipei) |
| Trial ID | NCT05914038 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of individualized repetitive transcranial magnetic stimulation (rTMS) tailored to the lateralization index in enhancing motor recovery and cortical excitability in patients who have experienced a stroke. The approach utilizes both high and low-frequency rTMS to modulate cerebral cortex excitability, with a focus on subacute stroke patients within three months of their event. Unlike previous studies that applied a uniform rTMS protocol, this study aims to personalize treatment based on individual patient characteristics. The goal is to determine if this tailored approach can lead to better recovery outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 20 who have experienced a unilateral ischemic or hemorrhagic stroke within the last three months and have limited upper limb strength.
Not a fit: Patients with a history of previous strokes, significant neurological disorders, or contraindications to rTMS may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for motor recovery in stroke patients.
How similar studies have performed: While traditional rTMS has been studied in stroke rehabilitation, this individualized approach based on lateralization index is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Unilateral ischemic or hemorrhagic stroke 2. Stroke within 3 months 3. Medical Research Council Scale for Muscle Strength in upper limb ≤ 3 4. No previous stroke, seizure, dementia, Parkinson's disease or other degenerative neurological diseases. 5. Patient could sit over 15 minutes 6. Age over 20 Exclusion Criteria: 1. Previous stroke, traumatic brain injury, brain tumor 2. With central nervous system disease (spinal cord injury, Parkinson's disease) 3. Any contraindication to rTMS (seizure, alcoholism, metal implant, pacemaker) 4. Patients unable to cooperate the treatment 5. Pregnancy 6. Depression
Where this trial is running
Taipei County, Taipei
- National Taiwan University Hospital — Taipei County, Taipei, Taiwan (Recruiting)
Study contacts
- Principal investigator: Meng Ting Lin, M.D. — The Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital
- Study coordinator: Meng Ting Lin, M.D.
- Email: b96401093@ntu.edu.tw
- Phone: +886-2312-3456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.