Individualized blood management for non-cardiac surgeries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effects of individualized acute normovolemic hemodilution (ANH) on the need for red blood cell transfusions in adults undergoing non-cardiac surgeries with expected significant blood loss. The study aims to reduce the complications associated with allogeneic blood transfusions by employing a technique that dilutes blood volume while maintaining normal blood pressure. Participants will be randomly assigned to receive individualized ANH or standard care to evaluate the effectiveness of this approach in minimizing transfusion requirements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing elective non-cardiac surgery with an anticipated red blood cells transfusion \>8 units (or 1600ml)
* Aged 18\~75 years
* Preoperative Hb level \> 120g/L for men and \> 110g/L for women.

Exclusion Criteria:

* Refusal of blood transfusion
* Cardiopulmonary insufficiency
* Cerebrovascular disease
* Renal impairment
* Hemoglobinopathies or blood system diseases
* Other situations not suitable for inclusion in clinical trial.

Where it's running

• West China Hospital of Sichuan University
  Chengdu, Sichuan, China Recruiting

Study contacts

• Principal investigator: Ren Liao — West China Hospital
• Study coordinator: Ren Liao, M.D.
• Email: liaoren7733@163.com
• Phone: +86-18980602177

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Effects of fluid infusion rates on blood circulation during surgery

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• Improving oxygen delivery during blood transfusions with S-nitrosylation therapy

  This study is testing if a special treatment can improve oxygen delivery to tissues during blood transfusions to help people feel better after receiving stored red blood cells.

  Recruiting Phase 1 Case Western Reserve University · Cleveland, Ohio · NCT03999229

• Examining how blood transfusion practices affect ICU patient outcomes

  This study looks at how blood transfusion practices impact the recovery of patients in intensive care units to see if better monitoring can lead to improved outcomes.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT03934112

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.