IndigeQuit: a culturally tailored quit-smoking smartphone program for American Indian and Alaska Native adults
Digital Smoking Cessation Intervention for Nationally-Recruited American Indians and Alaska Natives: A Full-Scale Randomized Controlled Trial (IndigeQuit)
This project tests whether the IndigeQuit smartphone app helps American Indian and Alaska Native adults quit smoking more effectively than the NCI QuitGuide app.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 776 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fred Hutchinson Cancer Center Academic / other |
| Locations | 1 site (Seattle, Washington) |
| Trial ID | NCT06145763 on ClinicalTrials.gov |
What this trial studies
Eligible participants who self-identify as American Indian or Alaska Native, are 18 or older, and smoke daily are randomized to use either the IndigeQuit app or the NCI QuitGuide app and asked to use it for at least 45 days. The IndigeQuit arm includes a personalized quit plan, eight progressive content levels, on-demand coping tools, and daily smoking tracking; the comparator arm uses the NCI QuitGuide app. Participants provide biospecimens and complete surveys, and outcomes are assessed at 3, 6, and 12 months. The intervention is delivered remotely via participants' own smartphones and excludes those currently using other cessation behavioral or pharmacologic treatments.
Who should consider this trial
Good fit: Ideal candidates are AI/AN adults (18+) who smoke daily, want to quit within 30 days, can read English, own an Android or iPhone, are willing to be randomized, and can complete follow-up assessments.
Not a fit: People without a personal smartphone, who cannot read English, who are already using other smoking cessation treatments, or who are not ready to quit in the next month are unlikely to benefit from enrolling.
Why it matters
Potential benefit: If successful, IndigeQuit could provide a low-cost, culturally tailored, widely accessible way for more American Indian and Alaska Native smokers to quit.
How similar studies have performed: Mobile smoking-cessation apps have produced modest improvements in quit rates in general populations, but culturally tailored digital interventions for AI/AN people are novel and less well tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-identify as American Indian or Alaska Native, either alone or in combination with other races * Age 18 and older * Has smoked daily for the past year * Interest in quitting smoking within the next 30 days * Willing to be randomly assigned to either app * Have daily access to their own Android or iPhone * Able to download a smartphone app * Be willing and able to read English * Not currently or within past 30 days using other smoking cessation behavioral interventions or smoking cessation pharmacotherapies * Have never participated in our prior research * Have no other household or family member participating * Being willing to complete the 3, 6, and 12-month follow-up assessments * Providing email, phone number(s), and mailing address * Living off United States (US) AI/AN tribal reservations or living on five Northern Plains tribal reservations from whom we would obtain approvals to recruit Exclusion Criteria: * Currently (i.e., within past 30 days) using other smoking cessation behavioral interventions * Has participated in our prior research trials * Has used the National Cancer Institute's (NCI's) QuitGuide app * Not willing to complete a follow-up survey at 3, 6, and 12 months post-randomization * Not providing email, phone number(s), and mailing address
Where this trial is running
Seattle, Washington
- Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States (Recruiting)
Study contacts
- Principal investigator: Jonathan B. Bricker — Fred Hutch/University of Washington Cancer Consortium
- Study coordinator: Brie Sullivan
- Email: bsulliva@fredhutch.org
- Phone: 206-667-5238
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.