Increasing measles vaccination coverage with nutrient supplements in young children
NutriVax-Measles: Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months, a Pragmatic Parallel Cluster-randomized Controlled Trial in Yobe State, Northern Nigeria
This study is testing whether giving young children nutrient supplements along with their regular vaccinations can help more kids get vaccinated against measles in Nigeria.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3720 (estimated) |
| Ages | 6 Months to 23 Months |
| Sex | All |
| Sponsor | Alliance for International Medical Action Academic / other |
| Locations | 1 site (Damaturu, Yobe) |
| Trial ID | NCT06387511 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of providing small-quantity lipid-based nutrient supplements (SQ-LNS) alongside routine immunization programs to improve measles vaccination coverage in children aged 6-23 months. It involves a pragmatic parallel cluster randomized trial conducted in 20 wards of Yobe state, Nigeria, where the impact of SQ-LNS on vaccination rates will be assessed through household surveys. The study also aims to identify barriers and facilitators to vaccination from the perspectives of parents, healthcare providers, and community health workers, while analyzing the cost-effectiveness of the intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 6-23 months residing in the targeted local government areas of Yobe state.
Not a fit: Patients with acute malnutrition or known medical complications that require hospitalization may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly increase measles vaccination rates and improve overall child health in malnourished populations.
How similar studies have performed: Other studies have shown promising results with similar approaches using nutritional supplements to improve health outcomes, indicating potential for success in this intervention.
Eligibility criteria
Show full inclusion / exclusion criteria
* Baseline and endline cross-sectional household surveys Inclusion criteria * Aged 12-23 months; * With oral informed consent of parent or legal guardian; * Residing in the catchment settlements of wards included in the study. Exclusion criteria * Included in the longitudinal follow-up. * Longitudinal follow-up survey Inclusion criteria * Aged 6-12 months; * With written informed consent of parent or legal guardian; * Residing in the catchment settlements of wards included in the study. Exclusion criteria * Acute malnutrition criteria as per the WHO definition (i.e. MUAC\< 125 or WHZ \< -2 or nutritional edema); * - Known medical complication that requires referral for hospitalization; * Known allergies to SQ-LNS or SQ-LNS contraindication; * Any other condition interfering with protocol adherence or the ability to give informed consent, in the judgment of the Field Investigator Sampling for HHS and LS will be carried out in three stages in each LGA using probability proportional to size (PPS). * Qualitative feasibility and acceptability survey Inclusion * Parent or legal guardian of a child aged 6-23 months and residing in the catchment settlements of wards included in the study, or Health worker of the ministry of health involved in the study,or Community representative or Community health workers; * With written informed consent.
Where this trial is running
Damaturu, Yobe
- All Primary Health Care Centers of Nguru and Karasuwa LGAs — Damaturu, Yobe, Nigeria (Recruiting)
Study contacts
- Principal investigator: Renaud Becquet, PhD — Institut National de la Santé Et de la Recherche Médicale, France
- Study coordinator: Cécile Cazes, PhD
- Email: cecile.cazes@coral.alima.ngo
- Phone: +33 (0)780589742
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.