In-depth investigation of the immune response to COVID-19
In-depth Characterisation of the Dynamic Host Immune Response to Coronavirus SARS-CoV-2
This study looks at the immune responses of hospitalized COVID-19 patients to see what makes some people get sicker than others.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT04327570 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize the clinical and immunological features of patients hospitalized with COVID-19 at UZ Leuven. It will collect various biological samples, including blood and respiratory secretions, from patients with confirmed SARS-CoV-2 infection to identify factors that contribute to severe disease. The study will compare characteristics between patients with severe and non-severe COVID-19, as well as between COVID-19 positive and negative controls, to enhance understanding of the immune response to the virus.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are hospitalized with confirmed SARS-CoV-2 infection.
Not a fit: Patients under 18 years old or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to targeted medical interventions for patients at high risk of severe COVID-19.
How similar studies have performed: Other studies have shown success in characterizing immune responses to COVID-19, making this approach both relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \>/= 18 years old AND * Hospitalised with PCR-confirmed and/or CT-confirmed SARS-CoV-2 disease Exclusion Criteria: * Age \< 18 years old * No informed consent
Where this trial is running
Leuven
- UZ Leuven — Leuven, Belgium (Recruiting)
Study contacts
- Principal investigator: Joost Wauters, MD PhD — UZ Leuven
- Study coordinator: Joost Wauters, MD PhD
- Email: joost.wauters@uzleuven.com
- Phone: 003216344275
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.