Improving turning ability in people with Parkinson's Disease
Mobility in Daily Life and Falls in Parkinson's Disease: Potential for Rehabilitation
This study is testing a special exercise program to see if it can help people with Parkinson's Disease turn better in their daily lives.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Trial ID | NCT04897256 on ClinicalTrials.gov |
What this trial studies
This intervention aims to evaluate the effectiveness of the TURN-IT exercise program designed to enhance turning quality in individuals with Parkinson's Disease (PD). Participants will be randomized into either a TURN-IT group, which involves tailored exercises addressing specific physical constraints, or a No-Intervention Control group over a 6-week period. The study will assess changes in turning ability and daily-life turning quality measures, such as the number of steps to turn and turn velocity. The findings will help determine the feasibility of a larger clinical trial.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 55-85 with idiopathic Parkinson's Disease, experiencing falls, and responsive to levodopa.
Not a fit: Patients with major musculoskeletal or neurological disorders, or those unable to participate in exercise due to health conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the turning ability and overall mobility of patients with Parkinson's Disease, potentially reducing fall risk.
How similar studies have performed: While this specific approach is novel, similar interventions targeting mobility in Parkinson's Disease have shown promise in improving patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of idiopathic PD from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with 1 or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions 2. Responsive to levodopa 3. Hoehn \& Yahr stages II-IV 4. Age range 55-85 years old 5. self-report of one or more falls in past 12 months 6. willing and able to attend exercise intervention sessions at OHSU campus, and also refrain from changes in anti-parkinson medications and exercise levels. Exclusion Criteria: 1. Major musculoskeletal or neurological disorders, structural brain disease, epilepsy, acute illness or health history, other than PD 2. no medical condition that precludes exercise 3. MoCA ≤ 21 or inability to follow directions 4. excessive use of alcohol or recreational drugs 5. recent change in medication 6. inability to stand and walk for 2 minutes without an assistive device
Where this trial is running
Portland, Oregon
- Oregon Health & Science University — Portland, Oregon, United States (Recruiting)
Study contacts
- Principal investigator: Fay Horak, PhD, PT — Oregon Health and Science University
- Study coordinator: Jacquie Ellison
- Email: balance@ohsu.edu
- Phone: 503-329-3828
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.