Improving treatment for acute deep vein thrombosis in the whole lower limb

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates a new approach to pharmacomechanical thrombectomy (PMT) for patients with acute deep vein thrombosis (DVT) affecting the entire lower limb. The study aims to adjust the access point for the procedure to enhance thrombus clearance and reduce the risk of post-thrombotic syndrome (PTS). By targeting the iliac vein and other key areas, the researchers hope to improve outcomes for patients who have experienced DVT symptoms for less than 14 days. The trial will include patients aged 18-80 who meet specific inclusion criteria and will exclude those with certain medical conditions or previous DVT history.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18-80 years old;
* Acute DVT with clinical symptoms occurred less than 14 days since the onset of disease;
* DVT with thrombosis involving the iliac vein, common femoral vein, distal popliteal vein, and/or calf vein;
* Informed consent signed by patients.

Exclusion Criteria:

* Patients with the previous history of the same side of lower-limb DVT;
* Patients with plasma Creatinine level greater than 180umol/L;
* Patients who are contraindicated to thrombolysis;
* Patients with inferior vena cava thrombosis;
* Patients who are known to be allergic to heparin, low molecular weight heparin, or contrast agent;
* Patients who have participated in a clinical trial in the past three months;
* Women during pregnancy and lactation
* Patients with other diseases that may cause difficulty in the study or significantly shorten the life expectancy of patients (\<2 years);
* Patients with autoimmune thrombopathy or thrombocytopenia (platelets \< 80·10⁹/L);
* Patients who are unable or unwilling to participate in the study.

Where it's running

• Renji Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Ni Qihong, M.D.
• Email: niqihong1989@163.com
• Phone: +8615801900772

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Collecting ultrasound images to improve DVT detection

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• Using machine learning to quickly detect deep vein thrombosis

  This study is testing if a new machine learning tool can help doctors quickly rule out deep vein thrombosis in patients without needing an ultrasound every time.

  Recruiting Ostfold Hospital Trust · Sarpsborg · NCT06842446

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.