Improving screening for pulmonary hypertension using echocardiography
Improving Pulmonary Hypertension Screening by Echocardiography
This study is testing a new method to see if a special algorithm can help doctors find pulmonary hypertension in patients who might not show obvious signs of it during heart ultrasound exams.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Royal United Hospitals Bath NHS Foundation Trust Academic / other |
| Locations | 5 sites (Bath, Banes and 4 other locations) |
| Trial ID | NCT06038149 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of the IMPULSE algorithm in detecting pulmonary hypertension (PH) in patients with low or intermediate probability of PH, as per established guidelines. It will involve a prospective, multi-centre approach, recruiting patients referred for transthoracic echocardiography across several NHS hospitals. Comprehensive echocardiographic imaging and analysis will be conducted to identify patients who may be at risk for PH, focusing on specific right heart function metrics. The study will span 18 months, allowing for longitudinal assessment of the participants.
Who should consider this trial
Good fit: Ideal candidates include individuals experiencing unexplained breathlessness or those with risk factors for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Not a fit: Patients with a high probability of pulmonary hypertension or known congenital heart disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of pulmonary hypertension, enhancing patient outcomes.
How similar studies have performed: Other studies have shown promise in using echocardiographic techniques for detecting pulmonary hypertension, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unexplained breathlessness * Risk factors for Pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension (CTEPH) * Unexplained elevation of B-type natriuretic peptide (BNP/proBNP) * Referred for catheterisation. Exclusion Criteria: * ESC / BSE echo high probability of PH * Known or suspected congenital heart disease * Patients unlikely to benefit from management of PH or its underlying causes.
Where this trial is running
Bath, Banes and 4 other locations
- Royal United Hospital NHS Foundation Trust — Bath, Banes, United Kingdom (Recruiting)
- Golden Jubilee Hospital — Glasgow, Lanarkshire, United Kingdom (Not_yet_recruiting)
- Sheffield Teaching Hospitals NHS Foundation Trust — Sheffield, South Yorkshire, United Kingdom (Recruiting)
- Royal Papworth Hospital — Cambridge, United Kingdom (Not_yet_recruiting)
- Royal Free NHS Foundation Trust — London, United Kingdom (Not_yet_recruiting)
Study contacts
- Principal investigator: Daniel X Augustine, BSc(Hons) — Royal United Hospitall NHS Foundation Trust
- Study coordinator: Christopher JB Wild, BSc(Hons)
- Email: chris.wild1@nhs.net
- Phone: 07891662866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.