Improving recovery after general anesthesia in elderly patients
Dexmedetomidine Combined With Nalbuphine Advanced Analgesia on the Quality of Recovery After General Anesthesia in Elderly Patients
This study tests whether using nalbuphine and dexmedetomidine can help elderly patients recover more comfortably and with less agitation after general anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 360 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Tianjin First Central Hospital Academic / other |
| Locations | 2 sites (Tianjin, Tianjin and 1 other locations) |
| Trial ID | NCT05769530 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of nalbuphine and dexmedetomidine on the recovery quality of elderly patients undergoing general anesthesia. It focuses on reducing postoperative agitation and complications associated with the recovery period. The study will assess the occurrence of agitation within 30 minutes after anesthesia and evaluate the efficacy of these medications in enhancing patient outcomes. By utilizing these drugs, the study aims to minimize discomfort and improve the overall recovery experience for elderly patients.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 60 and above who require general anesthesia and are on ventilator support post-intubation.
Not a fit: Patients with allergies to the study drugs, severe bradycardia, or significant hepatic and renal dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery experiences and reduced complications for elderly patients after surgery.
How similar studies have performed: Previous studies have shown that similar approaches using nalbuphine and dexmedetomidine can effectively reduce postoperative agitation and improve recovery outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * (1) Age ≥60, gender unlimited; (2) ventilator assisted ventilation after endotracheal intubation; (3) General anesthesia surgery; Exclusion Criteria: * (1) Allergy to the drugs used in this study; (2) any sedative, analgesic, antiemetic or antipruritic drugs taken 24 hours before the operation; (3) History of severe bradycardia (heart rate \< 50 beats/min); (4) moderate to severe hepatic and renal dysfunction; (5) Patients with neurological diseases;
Where this trial is running
Tianjin, Tianjin and 1 other locations
- TianJin First Central Hospital — Tianjin, Tianjin, China (Recruiting)
- Tian Jin First Center Hospital — Tianjin, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.