Improving ovarian tissue reimplantation with platelet-enriched plasma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of injecting autologous platelet-enriched plasma into the ovaries during the transplantation of cryopreserved ovarian tissue. The goal is to enhance the outcomes of this procedure for women experiencing premature ovarian failure or irregular menstrual cycles. Participants will undergo a thorough screening process to ensure eligibility, including tests for infections and neoplastic contamination. The study aims to improve ovarian endocrine function and increase the chances of live births following transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* request for cryopreserved ovarian tissue transplantation;
* premature ovarian failure or irregular mentrual cycles;
* negative test for HIV, HBV, HCV, Treponema pallidum;
* negative PAP test;
* oncological authorization;
* absence of neoplastic contamination in the cryopreserved ovarian tissue;
* Informed consent

Exclusion Criteria:

* neoplastic contamination in cryopreserved ovarian tissue;
* history of endometriosis;
* endocrinological disorders present and not treated (uncompensated thyroid dysfunction, diabetes (type 1, type 2);
* body mass index (BMI) \>30 kg/m2;
* circulating platelet level \< 150,000 / mml;
* bacterial infection;
* ongoing use of anticoagulants;
* bleeding diathesis.

Where it's running

• Diego Raimondo
  Bologna, Bo, Italy Recruiting

Study contacts

• Study coordinator: Diego Raimondo, MD
• Email: die.raimondo@gmail.com
• Phone: 0512143732

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.