Improving non-invasive monitoring of metabolite levels using MR spectroscopy techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to enhance magnetic resonance spectroscopy (MRS) methods to improve the sensitivity, accuracy, and stability of metabolite measurements in healthy subjects. The study will develop and optimize new MRS techniques to visualize previously undetectable metabolites and assess changes over time or after exercise. The methodology will be validated through in vitro tests followed by trials in healthy participants using certified MRI scanners. The ultimate goal is to make these advanced MRS techniques suitable for routine clinical applications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* signed informed consent
* healthy (no neuronal or metabolic diseases as stated by the study participant)
* able to lie still in the MR scanner for at least one hour

Exclusion Criteria:

* \<18 yrs of age
* pregnancy or current state of lactation
* active implants
* passive ferromagnetic implants
* passive non-ferromagnetic metallic implants \> 4 cm inside a region covered by the active radio-frequency (RF) coils
* large tattoos inside a region covered by the active RF coils
* known or suspected non-compliance,
* under-weight (\<35 kg body weight)

Where it's running

• Translational Imaging Center
  Bern, PhD, Switzerland Recruiting

Study contacts

• Principal investigator: Roland Kreis, PhD — Inselspital Bern & University Bern
• Study coordinator: Roland Kreis, PhD
• Email: roland.kreis@insel.ch
• Phone: +41316328174

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.