Improving non-invasive monitoring of metabolite levels using MR spectroscopy techniques
Evaluation of Novel and Adapted MR Spectroscopy and Metabolic Imaging Techniques for Non-invasive Monitoring of Metabolite Levels in Humans in Physiologic States of Everyday Life
This study is testing new MRI techniques to see if they can better measure certain substances in healthy people’s bodies over time or after exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 1 site (Bern, PhD) |
| Trial ID | NCT05165537 on ClinicalTrials.gov |
What this trial studies
This project aims to enhance magnetic resonance spectroscopy (MRS) methods to improve the sensitivity, accuracy, and stability of metabolite measurements in healthy subjects. The study will develop and optimize new MRS techniques to visualize previously undetectable metabolites and assess changes over time or after exercise. The methodology will be validated through in vitro tests followed by trials in healthy participants using certified MRI scanners. The ultimate goal is to make these advanced MRS techniques suitable for routine clinical applications.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults who can lie still in an MRI scanner for at least one hour.
Not a fit: Patients with neuronal or metabolic diseases, those under 18 years of age, or individuals with certain implants or large tattoos may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and reliable non-invasive assessments of metabolic conditions in patients.
How similar studies have performed: Other studies have shown promise in enhancing MRS techniques, but this specific approach is novel and aims to extend current capabilities.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * signed informed consent * healthy (no neuronal or metabolic diseases as stated by the study participant) * able to lie still in the MR scanner for at least one hour Exclusion Criteria: * \<18 yrs of age * pregnancy or current state of lactation * active implants * passive ferromagnetic implants * passive non-ferromagnetic metallic implants \> 4 cm inside a region covered by the active radio-frequency (RF) coils * large tattoos inside a region covered by the active RF coils * known or suspected non-compliance, * under-weight (\<35 kg body weight)
Where this trial is running
Bern, PhD
- Translational Imaging Center — Bern, PhD, Switzerland (Recruiting)
Study contacts
- Principal investigator: Roland Kreis, PhD — Inselspital Bern & University Bern
- Study coordinator: Roland Kreis, PhD
- Email: roland.kreis@insel.ch
- Phone: +41316328174
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.