Improving muscle function in type 1 diabetes with resveratrol

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate whether resveratrol supplementation for 12 weeks can enhance endothelin-B receptor function and mitochondrial function in skeletal muscle among individuals with type 1 diabetes. The researchers will utilize innovative, minimally invasive techniques such as intradermal microdialysis and near infrared spectroscopy to assess these functions. The central hypothesis is that increasing circulating Sirt1 through resveratrol will lead to improvements in both receptor and muscle function, potentially lowering cardiovascular disease risk in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and premenopausal women
* All races
* Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)

Exclusion Criteria:

* Clinical diagnosis of hepatic, cardiovascular, or renal disease
* Uncontrolled diabetes (HbA1C \>12%)
* Diabetic complications (i.e. neuropathy)
* Uncontrolled hypertension (\>140/90 mm Hg on therapy)
* Pregnancy
* Use of vasoactive medications

Where it's running

• Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
  Augusta, Georgia, United States Recruiting

Study contacts

• Study coordinator: Ryan A Harris, PhD, CEP
• Email: ryharris@augusta.edu
• Phone: 7067215998

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.