Improving MRI imaging for brain surgery planning
Visualization of Neural Targets With 3T MRI
This study is testing new MRI techniques to see if they can help doctors better plan brain surgeries for patients needing treatments like deep brain stimulation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT05175417 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enhance the visualization of neural targets in the brain using advanced 3T MRI sequences prior to functional neurosurgery procedures. By comparing the image quality of various MRI settings in patients scheduled for interventions like deep brain stimulation and healthy controls, the study seeks to identify optimal imaging techniques. The research will be conducted at Toronto Western Hospital, where multiple advanced MRI sequences will be tested against conventional methods to improve preoperative planning for neurosurgical treatments.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 85 who are preparing for functional neurosurgical interventions at Toronto Western Hospital.
Not a fit: Patients with contraindications for MRI or serious cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better preoperative imaging, improving the accuracy of functional neurosurgery and potentially enhancing patient outcomes.
How similar studies have performed: Previous studies have shown success with advanced MRI techniques in similar contexts, suggesting potential for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 85 years of age. * Preparing to undergo a functional neurosurgical intervention (e.g., DBS, RFA, GKR or MRgFUS) at TWH (not applicable for healthy volunteers). * Participants must be able to understand the purpose of this research and must sign the informed consent form. * Participants must understand that the role of this research is to enhance our understanding of brain functioning and that he/she will not directly or indirectly benefit from the study. Exclusion Criteria: * Contraindication for an MRI (e.g., implanted cardiac device, metal in eyes, aneurysm clip, etc.). * Participants who have serious cognitive or psychological impairments and cannot give informed consent. * Participants who are unable to communicate effectively or efficiently (e.g., patients suffering from speech deficits (dysarthria, aphasia) or are non-English speaking).
Where this trial is running
Toronto, Ontario
- Toronto Western Hospital — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Andres M Lozano, MD/PhD — University Health Network, Toronto, ON
- Study coordinator: Tasnuva T Hoque, BSc
- Email: tasnuva.hoque@uhnresearch.ca
- Phone: 4166035800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.