Improving mental health for orphaned and vulnerable children in South Africa

MISC-CBO: a Cluster Randomized Control Trial to Improve the Mental Health of OVC in South Africa

Not applicable Interventional University of Houston · NCT05943132

This study is testing a new program to see if it can help caseworkers provide better care and improve the mental health of orphaned and vulnerable children in South Africa.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment792 (estimated)
Ages7 Years to 11 Years
SexAll
SponsorUniversity of Houston Academic / other
Locations1 site (Bloemfontein, Free State)
Trial IDNCT05943132 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of the Mediational Intervention for Sensitizing Caregivers for Community-based Organizations (MISC-CBO) in enhancing the caregiving quality of caseworkers and improving mental health outcomes for orphaned and vulnerable children (OVC) in South Africa. The study involves a cluster randomized control design with 24 community-based organizations (CBOs) and aims to assess the impact of MISC-CBO over a 24-month period. Participants include 360 children aged 7-11 and 72 caseworkers, with some CBOs receiving the intervention while others continue with standard treatment. The trial seeks to address the mental health challenges faced by OVC due to factors like HIV/AIDS and poverty.

Who should consider this trial

Good fit: Ideal candidates for this study are orphaned and vulnerable children aged 7-11 who reside in the catchment area of participating community-based organizations.

Not a fit: Children with serious birth complications, severe malnutrition, or neurological disabilities may not benefit from this intervention.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the mental health and well-being of orphaned and vulnerable children in South Africa.

How similar studies have performed: While this approach is novel in the context of community-based organizations in South Africa, similar interventions have shown success in other regions, particularly in Uganda.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Status as OVC.
2. Children will be 7-11 years old
3. Resident in the CBO catchment area
4. Child has a legal guardian

Exclusion Criteria:

1. Children with a medical history of serious birth complications
2. Children with a medical history severe malnutrition
3. Children with a neurological disability

Where this trial is running

Bloemfontein, Free State

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Mental Disorder, Childmental health problemsMediational Intervention for Sensitizing Caregiversmentalizingcaregivers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.