Improving memory in multiple sclerosis patients using brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of transcranial Direct Current Stimulation (tDCS) on enhancing verbal retrieval and cognitive functions in patients with relapsing-remitting multiple sclerosis. Participants will be randomly assigned to receive either active tDCS or sham treatment over ten sessions, with assessments conducted before, immediately after, and two months following the intervention. The study will also explore how baseline cognitive assessments and concussion history may influence treatment outcomes. By comparing the two treatment arms, the research seeks to determine the potential benefits of tDCS in addressing cognitive deficits associated with multiple sclerosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

º Diagnosed with relapsing-remitting multiple sclerosis (RRMS)

º Memory retrieval deficit based on neuropsychological testing done in our lab

º Must be fluent in speaking and reading English.

Exclusion Criteria:

º Relapse or acute MS exacerbation or a course of steroids in the two months preceding the testing

º Participants using benzodiazepines must have been on a stable dose for at least two months

º Potentially confounding psychological or neurological disorder, including:

* dementia of any type
* epilepsy or other seizure disorders
* severe traumatic brain injury
* brain tumor
* present drug abuse
* stroke
* blood vessel abnormalities in the brain
* Parkinson's disease
* Huntington's disease

º inability to give informed consent

º cranial implants

º skull defects that affect tDCS administration

º use of medications that interact with or potentially interact with tDCS effects, including:

* anti-convulsants
* L-dopa
* carbamazepine
* sulpiride
* pergolide
* lorazepam
* rivastigmine
* dextromethorphan
* D-cycloserine
* flunarizine
* ropinirole
* stimulants (dextroamphetamine/amphetamine/modafinil/armodafinil) must be stopped during enrollment

Where it's running

• The University of Texas at Dallas
  Richardson, Texas, United States Recruiting

Study contacts

• Principal investigator: John Hart, Jr, MD — The University of Texas at Dallas
• Study coordinator: Ashna Adhikari, MS
• Email: Ashna.Adhikari@UTDallas.edu
• Phone: 972-833-3161

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.