Improving lung function in ARDS patients using prone positioning
Improvement of Acute Respiratory Distress Syndrome Ventilation-perfusion Matching by Prone Positioning Assessed by Electrical Impedance Tomography
This study is testing if putting patients with Acute Respiratory Distress Syndrome face down can help improve their lung function and oxygen levels.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Chao Yang Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05765760 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effects of prone position ventilation on ventilation-perfusion (V/Q) matching in patients with Acute Respiratory Distress Syndrome (ARDS) using Electrical Impedance Tomography (EIT). The study hypothesizes that positioning patients face down can enhance lung recruitment and improve oxygenation by optimizing V/Q ratios. It will assess dynamic changes in lung function during repeated prone positioning, addressing gaps in previous research that primarily consisted of small-scale studies. The findings could provide valuable insights into effective ventilation strategies for ARDS management.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with ARDS who have been on invasive ventilation for less than 48 hours.
Not a fit: Patients who are hemodynamically unstable or have contraindications to prone positioning or EIT may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve oxygenation and reduce mortality rates in ARDS patients.
How similar studies have performed: Previous studies have shown promising results with prone positioning in ARDS, but this study aims to provide more comprehensive data on its effects using EIT, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old; 2. meet the diagnostic criteria of Berlin's definition for ARDS; 3. invasive ventilation time \< 48h; 4. PaO2/FiO2 \< 150mmHg. Exclusion Criteria: 1. Contraindication to the prone position; 2. Contraindication to the EIT; 3. Hemodynamically unstable; 4. Patients with hypernatremia; 5. Patients have received extracorporeal membrane oxygenation treatment.
Where this trial is running
Beijing, Beijing
- Beijing Chao-Yang Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Yu Zhao, Dr.
- Email: xuanben1985@163.com
- Phone: +8618601342030
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.