Improving kidney graft function from brain-dead organ donors
Impact of Perioperative Organ Resuscitation of Brain-dead Deceased Organ Donor on Kidney Graft Function in the Recipient
This study looks at how the care given to brain-dead organ donors can improve the function of kidneys transplanted to patients waiting for a transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT06907758 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how perioperative care of brain-dead organ donors can affect the quality and function of kidney grafts transplanted to recipients. By focusing on potentially modifiable factors in donor management, the study aims to enhance graft performance and reduce waiting times for kidney transplants. The research will analyze data from adult brain-dead patients who have undergone multi-organ transplantation and whose kidneys have been transplanted at Strasbourg University Hospital.
Who should consider this trial
Good fit: Ideal candidates include adult brain-dead organ donors and adult recipients of kidney transplants from these donors at Strasbourg University Hospital.
Not a fit: Patients who are not undergoing kidney transplantation or those who do not meet the donor or recipient criteria will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved kidney transplant outcomes and shorter waiting times for patients in need of a kidney.
How similar studies have performed: While the approach of optimizing donor management is established, the specific focus on perioperative organ resuscitation in brain-dead donors for kidney grafts is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: The inclusion criteria for organ donor patients are as follows: * Adult patient * Brain dead * Hospitalized in surgical intensive care at Strasbourg University Hospital (NHC cardiovascular intensive care unit, NHC multi-purpose intensive care unit, Hautepierre surgical intensive care unit) from January 1, 2018 to December 31, 2023 * Having undergone multi-organ transplantation * At least one of the donor kidneys has been transplanted to a patient at Strasbourg University Hospital * Absence of written objection in the medical file of the subject (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes. The inclusion criteria for kidney transplant recipients are as follows: * Adult patient * Recipient of a kidney transplant from an organ donor who meets the inclusion criteria for donor patients mentioned above * Patient who has undergone surgery and is hospitalized post-operatively at Strasbourg University Hospital * Patient monitored by the Strasbourg University Hospital transplant team * Absence of written objection in the subject's medical file (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes. Exclusion Criteria: * Subject (and/or their legal representative, if applicable) who has expressed their opposition to the reuse of their data for scientific research purposes * Brain-dead patient who has not undergone organ retrieval * Brain-dead patient whose kidney has not been allocated to a recipient in Strasbourg * Patient transferred to the Strasbourg University Hospital's intensive care unit from another hospital in a state of already diagnosed brain death solely for organ retrieval * Kidney transplant patient with a graft from a living donor * Kidney transplant patient with a graft from a deceased donor who is not brain-dead * Kidney transplant patient with a graft from a deceased donor who is brain-dead and hospitalized in a hospital other than Strasbourg
Where this trial is running
Strasbourg
- Service d'Anesthésie, Réanimation et Médecine Périopératoire - CHU de Strasbourg - France — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Charlotte POUSSARDIN, MD
- Email: charlotte.poussardin@chru-strasbourg.fr
- Phone: 33.3.69.55.16.21
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.