Improving kidney graft function from brain-dead organ donors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how perioperative care of brain-dead organ donors can affect the quality and function of kidney grafts transplanted to recipients. By focusing on potentially modifiable factors in donor management, the study aims to enhance graft performance and reduce waiting times for kidney transplants. The research will analyze data from adult brain-dead patients who have undergone multi-organ transplantation and whose kidneys have been transplanted at Strasbourg University Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The inclusion criteria for organ donor patients are as follows:

* Adult patient
* Brain dead
* Hospitalized in surgical intensive care at Strasbourg University Hospital (NHC cardiovascular intensive care unit, NHC multi-purpose intensive care unit, Hautepierre surgical intensive care unit) from January 1, 2018 to December 31, 2023
* Having undergone multi-organ transplantation
* At least one of the donor kidneys has been transplanted to a patient at Strasbourg University Hospital
* Absence of written objection in the medical file of the subject (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes.

The inclusion criteria for kidney transplant recipients are as follows:

* Adult patient
* Recipient of a kidney transplant from an organ donor who meets the inclusion criteria for donor patients mentioned above
* Patient who has undergone surgery and is hospitalized post-operatively at Strasbourg University Hospital
* Patient monitored by the Strasbourg University Hospital transplant team
* Absence of written objection in the subject's medical file (and/or their legal representative, if applicable) to the reuse of their data for scientific research purposes.

Exclusion Criteria:

* Subject (and/or their legal representative, if applicable) who has expressed their opposition to the reuse of their data for scientific research purposes
* Brain-dead patient who has not undergone organ retrieval
* Brain-dead patient whose kidney has not been allocated to a recipient in Strasbourg
* Patient transferred to the Strasbourg University Hospital's intensive care unit from another hospital in a state of already diagnosed brain death solely for organ retrieval
* Kidney transplant patient with a graft from a living donor
* Kidney transplant patient with a graft from a deceased donor who is not brain-dead
* Kidney transplant patient with a graft from a deceased donor who is brain-dead and hospitalized in a hospital other than Strasbourg

Where it's running

• Service d'Anesthésie, Réanimation et Médecine Périopératoire - CHU de Strasbourg - France
  Strasbourg, France Recruiting

Study contacts

• Study coordinator: Charlotte POUSSARDIN, MD
• Email: charlotte.poussardin@chru-strasbourg.fr
• Phone: 33.3.69.55.16.21

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.