Improving intubation success with topical anesthesia
Topical Oral Anesthesia Adjuncts in Conventional Intubation: A Randomized Controlled Trial Evaluating the Impact of Topical Oral Anesthesia on First-pass Success Rate
This study is testing if using a lidocaine spray before intubation can help doctors successfully place a breathing tube on the first try for patients in Thailand.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Queen Savang Vadhana Memorial Hospital, Thailand Academic / other |
| Locations | 1 site (Chon Buri, Changwat Chon Buri) |
| Trial ID | NCT06661967 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of topical oral anesthesia in enhancing the first-pass success rate of intubation using video laryngoscopy. Conducted in Thailand, where conventional intubation is commonly performed without paralysis, the study builds on previous pilot findings that suggest topical anesthesia may improve outcomes. Participants will receive lidocaine spray prior to intubation to assess its impact on various intubation parameters.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old in the emergency department requiring conventional intubation.
Not a fit: Patients undergoing rapid sequence intubation, those in cardiac arrest, pregnant individuals, or those with a known allergy to lidocaine may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve intubation success rates in emergency settings, leading to better patient outcomes.
How similar studies have performed: Previous pilot studies have shown promising results with similar approaches, indicating potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients in emergency department that have indication for conventional intubation * Age \> 18 yr Exclusion Criteria: * Patient who undergo RSI * Patient who falls in cardiac arrest airway algorithm * Patient who is currently pregnancy * Known allergy to lidocaine
Where this trial is running
Chon Buri, Changwat Chon Buri
- Queen Savang Vadhana Memorial Hospital — Chon Buri, Changwat Chon Buri, Thailand (Recruiting)
Study contacts
- Study coordinator: Sila Thammongkol
- Email: Sila_th@outlook.com
- Phone: 0853510161
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.