Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Improving how people tolerate upsetting feelings

Official title: Targeting Components of Distress Tolerance

Run by University of Arkansas, Fayetteville · NCT06570603 · Data updated 2026-11-12

This project will test whether brief trainings that increase willingness to feel upset and boost confidence for withstanding distress help adults with high emotional distress use better emotion-regulation strategies in daily life.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment240 (estimated)
SponsorUniversity of Arkansas, Fayetteville
Academic / other
Locations1 site (Fayetteville, Arkansas)
StatusRecruiting
StartedOctober 3, 2024
Main results expectedDecember 2026
Study endsApril 2027
Registry record updatedJuly 10, 2025
Trial IDNCT06570603 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults fluent in English who own an Android or iPhone, can regularly access their phone and internet, and have elevated symptom scores (DASS-21 ≥ 42) and Distress Intolerance Index ≥ 3 are ideal candidates.

Probably not a fit

People without a smartphone or reliable internet, those whose work or school prevents consistent phone access, and individuals with low symptom or distress-intolerance scores are unlikely to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with elevated depression, anxiety, or stress symptoms and higher distress intolerance use a smartphone app to report moods, willingness to feel upset, self-efficacy for withstanding distress, and emotion-regulation strategies multiple times per day for three weeks. Participants receive brief, targeted interventions focused on willingness, self-efficacy, or psychoeducation delivered through the app and related materials. The trial examines whether these trainings change momentary emotion-regulation strategy use and whether such changes are linked to reductions in mental health symptoms over time. Baseline and follow-up questionnaires supplement the daily phone-based measurements to track symptom change.

Why it matters

Potential benefit: If successful, this approach could help people manage upsetting emotions more effectively and reduce symptoms of anxiety and depression by improving moment-to-moment emotion regulation.

How similar studies have gone: Acceptance-based and self-efficacy interventions (for example, ACT and DBT skills training) have shown promise for improving distress tolerance and emotion regulation, but delivering brief targeted trainings via smartphone with intensive daily measurement is a relatively new approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Fluent in English
* Uses Android or iPhone smartphone
* Depression Anxiety and Stress Scale (DASS-21) scores of 42 and higher
* Distress Intolerance Index (DII) scores of 3 or higher

Exclusion Criteria:

* Work or School that does not allow consistent access to phone (or is unsafe)
* No internet access for completing follow-up surveys

Where it's running

  • University of Arkansas - Fayetteville
    Fayetteville, Arkansas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.