Improving heart function in heart failure patients with electrical conduction issues
Activation Pattern and Acute Hemodynamics of His and Left Bundle Pacing
This study is testing a new way to improve heart function in heart failure patients with electrical issues by using special pacing techniques to see if it works better than standard treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 27 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin) |
| Trial ID | NCT05556018 on ClinicalTrials.gov |
What this trial studies
This clinical investigation aims to evaluate the acute effects of His and left bundle pacing on heart function and conduction abnormalities in patients who are candidates for Cardiac Resynchronization Therapy (CRT). The study focuses on patients who may not respond to traditional CRT approaches, which typically involve placing pacing leads in standard locations. By utilizing electrical activation mapping, the study seeks to optimize pacing strategies for better outcomes. The goal is to enhance the effectiveness of CRT in patients with specific electrical conduction issues.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and above who are eligible for CRT therapy and have been on stable medical therapy for at least three months.
Not a fit: Patients who are pregnant or currently participating in another clinical study may not receive any benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve heart function and survival rates in heart failure patients with conduction abnormalities.
How similar studies have performed: While traditional CRT approaches have been established, this specific method of His and left bundle pacing is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (aged 18 or above) of both sexes * Candidate for CRT therapy according to international guidelines.7 * Informed consent by the patient * Already received stable dose of guideline directed medical therapy for at least 3 months Exclusion Criteria: * Pregnant * Participating in another study
Where this trial is running
Shatin
- The Chinese University of Hong Kong — Shatin, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Bryan Yan — Chinese University of Hong Kong
- Study coordinator: Daniel Xu
- Email: danielxu@cuhk.edu.hk
- Phone: 35051518
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.