Improving heart failure treatment with advanced imaging techniques
Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology: A Pilot Study
This study is testing if using advanced imaging techniques can improve heart failure treatment by helping doctors better program heart devices for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University Innsbruck Academic / other |
| Locations | 1 site (Innsbruck, Tyrol) |
| Trial ID | NCT04662970 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance cardiac resynchronization therapy (CRT) by analyzing the activation times of the left and right ventricles using non-invasive imaging techniques. It utilizes patient-specific anatomical data obtained from cardiac magnetic resonance imaging to create a semi-automated model that incorporates the conductivity of various tissues. The study employs a software package to calculate local activation times, which will help optimize CRT device programming algorithms for better patient outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients who have successfully received a CRT-D or CRT-P device and can undergo cardiac magnetic resonance imaging.
Not a fit: Patients with high-grade AV block, terminal heart failure, or contraindications to cardiac magnetic resonance imaging may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective heart failure treatments through personalized CRT programming.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in optimizing cardiac therapies through advanced imaging techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients after successful implantation of a CRT-D or CRT-P device in whom a cardiac magnetic resonance examination is possible and the device is equipped with the SyncAV® programming software * left bundle branch block before CRT implantation * PQ interval ≤ 250 ms before implantation Exclusion Criteria: * high-grade AV block * any contraindication concerning a safe CMR performance including claustrophobia * terminal heart failure (NYHA IV) or cardiac decompensation * life expectancy \< 1 year * women with child-bearing potential, pregnancy * drug abusus
Where this trial is running
Innsbruck, Tyrol
- Medical University Innsbruck — Innsbruck, Tyrol, Austria (Recruiting)
Study contacts
- Principal investigator: Wolfgang Dichtl, MD PhD — Medical University Innsbruck
- Study coordinator: Wolfgang Dichtl, MD PhD
- Email: dichtl@me.com
- Phone: 004351250481388
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.