Improving heart failure treatment through better medication use
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care (GREAT-HF Care)
This study is testing different ways to help doctors use heart failure medications better to see if it can improve treatment for people with heart failure and save lives.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 4300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Geisinger Clinic Academic / other |
| Locations | 1 site (Danville, Pennsylvania) |
| Trial ID | NCT05990296 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates strategies to enhance the use of guideline-directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF). It employs a cluster randomized design where clinicians are assigned to different intervention arms, including usual care and various forms of clinical decision support. The goal is to assess the effectiveness of these interventions in increasing the utilization of life-saving medications and ultimately reducing mortality and heart failure-related events. The study also explores the impact of educational rollouts on the effectiveness of these interventions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a diagnosis of heart failure with reduced ejection fraction who have visited participating Geisinger cardiology clinics.
Not a fit: Patients currently in hospice or palliative care, those allergic to GDMT medications, or those already prescribed all categories of GDMT may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved medication adherence and better health outcomes for patients with heart failure.
How similar studies have performed: Other studies have shown success in improving medication adherence through clinical decision support systems, indicating that this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years or older AND * Completed visit at included Geisinger cardiology outpatient clinics (office visit or telemedicine) AND * Clinicians are on a list of currently active Geisinger clinicians in outpatient cardiology clinics who can prescribe heart failure medications AND * Active problem list diagnosis of HFrEF at time of Cardiology clinic encounter OR Left Ventricular Ejection Fraction (LVEF) \< 40: most recent to the cardiology clinic encounter within 2 years of the visit. Exclusion Criteria: * Currently in hospice or palliative care (ICD 10 code: Z51.5) * Patient is allergic to each category of GDMT * Patient is prescribed medications from all four categories of GDMT, including ARNI specifically
Where this trial is running
Danville, Pennsylvania
- Geisinger Cardiology Clinics — Danville, Pennsylvania, United States (Recruiting)
Study contacts
- Study coordinator: Stephen J Voyce
- Email: svoyce@geisinger.edu
- Phone: 5707034830
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.