Improving follow-up after treatment for suspicious cervical lesions in Ethiopia
Official title: Key Interventions to Improve the Follow-up Adherence Post Cervical Precancerous Lesion Treatment in Ethiopia: A Pragmatic Randomized Controlled Trial
Run by Addis Ababa University · NCT06515301 · Data updated 2026-11-12
This project tests whether nurse phone calls, home visits by health extension workers, or automated SMS reminders help women keep follow-up appointments after treatment for suspicious cervical lesions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 49 Years |
| Sex | Women only |
| Enrollment | 466 (estimated) |
| Sponsor | Addis Ababa University Academic / other |
| Locations | 1 site (Silte, Southern Ethiopia) |
| Status | Recruiting |
| Started | November 20, 2024 |
| Main results expected | November 20, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | June 10, 2025 |
| Trial ID | NCT06515301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women treated for suspicious cervical lesions after a positive VIA screening at participating primary care sites who meet the age and HIV-status criteria and can give informed consent are eligible candidates.
✕Probably not a fit
Women with prior hysterectomy, diagnosed invasive cervical cancer, current pregnancy, active vaginal bleeding, prior screening history, or who cannot consent or be reached by the interventions are unlikely to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a pragmatic randomized trial conducted in primary health care settings in Silte, Southern Ethiopia, comparing three reminder approaches against standard care to improve post-treatment follow-up adherence. Participants are women treated for suspicious cervical lesions after a positive VIA screen, with age and HIV-status eligibility criteria. Interventions are structured nurse-led telephone call reminders, home-visit reminders by health extension workers, and an application-based automated SMS system, with adherence to scheduled follow-up as the primary outcome. The trial aims to determine which, if any, of these low-cost reminder strategies improves return rates in this low-resource setting.
Why it matters
Potential benefit: If successful, these reminder methods could raise follow-up rates and enable earlier detection and treatment, reducing progression to invasive cervical cancer.
How similar studies have gone: Similar reminder approaches such as phone calls and SMS have improved clinic attendance in other screening and appointment settings, though evidence specific to post-treatment cervical precancer follow-up in low-resource settings is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 30-49 (HIV-negative). * Women over 25 (HIV-positive). * Treated for suspicious cervical lesions after a positive VIA screening. Exclusion Criteria: * History of hysterectomy. * Diagnosis of other histological invasive cervical cancer. * Suspicious cervical cancer cases. * Pregnancy. * Prior screening history. * Vaginal bleeding. * Lack of consent.
Where it's running
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Worabe Health Center
Silte, Southern Ethiopia, Ethiopia Recruiting
Study contacts
- Study coordinator: Mr.Alemnew Destaw Mezgebu, MPH
- Email: alemrondesta66@gmail.com
- Phone: +251979695905
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.