Improving fertilization rates in women with previous fertilization failures using calcium ionophores.
Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore: a Prospective Randomized Study.
This study is testing if two different treatments can help women who have had trouble getting pregnant in the past by improving their egg fertilization rates and the quality of embryos.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Sex | Female |
| Sponsor | Instituto Valenciano de Infertilidad, IVI VALENCIA Academic / other |
| Locations | 1 site (Valencia) |
| Trial ID | NCT06106412 on ClinicalTrials.gov |
What this trial studies
This study investigates the efficacy of two types of calcium ionophores, ionomycin and A23187, in activating oocytes from women who have experienced fertilization failures in previous cycles. A total of 372 human oocytes from 44 women will be randomly assigned to receive one of the two treatments or serve as a control. The study aims to analyze fertilization rates, embryo development, and embryo quality, as well as follow obstetric outcomes of the offspring. By comparing the effectiveness of these two protocols, the study seeks to determine which method is more beneficial for improving reproductive outcomes.
Who should consider this trial
Good fit: Ideal candidates are women using their own oocytes who have previously experienced fertilization failures or have a fertilization rate of 30% or less.
Not a fit: Patients who are oocyte recipients or those with fewer than two mature oocytes after oocyte decumulation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance fertilization rates and reproductive success for women with a history of fertilization failure.
How similar studies have performed: Previous studies have shown improvements in fertilization and pregnancy rates with artificial oocyte activation, but this specific comparison of protocols is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Own oocyte patients who have had previous fertilization failure in previous cycles. * Own oocyte patients with fertilization rate in previous cycles less than or equal to 30% of the microinjected oocytes. Exclusion Criteria: * Oocyte Recipient Patients * Sperm bank sperm recipient patients * Patients who after oocyte decumulation have less than 2 mature oocytes.
Where this trial is running
Valencia
- Ivirma Valencia — Valencia, Spain (Recruiting)
Study contacts
- Study coordinator: LAURA CARACENA, Msr
- Email: LAURA.CARACENA@IVIRMA.COM
- Phone: 963.050900
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.