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Clinical trial Recruiting at 1 site Interventional Ages 18 to 24

Improving economic stability and HIV prevention for young adults in Baltimore

Official title: Education and Employment Support for HIV Prevention in Young Adults (ENSPIRE)

Run by University of North Carolina, Chapel Hill · NCT06096324 · Data updated 2026-11-12

This study is testing whether a program that helps young adults in Baltimore find jobs and learn about HIV prevention can improve their economic stability and health.

Quick facts

Study typeInterventional
Ages18 Years to 24 Years
SexAll
Enrollment500 (estimated)
SponsorUniversity of North Carolina, Chapel Hill
Academic / other
Locations1 site (Baltimore, Maryland)
StatusRecruiting
StartedSeptember 19, 2023
Main results expectedMarch 31, 2028
Study endsMarch 31, 2028
Registry record updatedMarch 4, 2026
Trial IDNCT06096324 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are African-American young adults aged 18 to 24 who are economically vulnerable, sexually active, and living in Baltimore.

Probably not a fit

Patients who are not economically vulnerable or are outside the age range of 18 to 24 may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the effectiveness of an enhanced microenterprise intervention aimed at improving economic stability and promoting HIV preventive behaviors among economically vulnerable young adults in Baltimore. Approximately 780 participants aged 18 to 24 will be randomly assigned to either a control group receiving job announcements via text or an intervention group receiving job announcements along with educational sessions, mentorship, micro-grants, and behavioral economics messages related to HIV prevention. The intervention will last for 12 weeks, with follow-up surveys conducted over two years to assess the impact on participants' economic and health outcomes.

Why it matters

Potential benefit: If successful, this intervention could significantly enhance economic stability and reduce HIV risk behaviors among vulnerable young adults.

How similar studies have gone: Other studies have shown promise in using economic interventions to improve health outcomes, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion criteria are:

* Aged 18-24
* Economically-vulnerable in past 12 months
* Sexually active in past 12 months
* Living in Baltimore
* Has access to mobile phone with text messaging

Exclusion criteria are:

* Aged 17 or younger
* Older than 24 years
* Unwilling to provide consent for study participation

Where it's running

  • Johns Hopkins University
    Baltimore, Maryland, United States     Recruiting

Study contacts

  • Principal investigator: Larissa Jennings Mayo-Wilson, PhD MHS — University of North Carolina, Chapel Hill
  • Study coordinator: Larissa Jennings Mayo-Wilson, PhD MHS
  • Email: ljennings.mayowilson@unc.edu
  • Phone: 919-445-5099

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.