Clinical trial Recruiting at 1 site Interventional Ages 50 to 80

Improving early lung cancer detection in diverse populations

Official title: Improving Detection of Early Lung Cancer in a Diverse Population

Run by British Columbia Cancer Agency · NCT06628102 · Data updated 2026-11-12

This study is trying to find a new way to spot lung cancer early in people who aren't eligible for regular screenings by using breath samples and blood tests to tell the difference between cancerous and non-cancerous growths.

Quick facts

Study typeInterventional
Ages50 Years to 80 Years
SexAll
Enrollment3600 (estimated)
SponsorBritish Columbia Cancer Agency
Academic / other
Locations1 site (Vancouver, British Columbia)
StatusRecruiting
StartedAugust 4, 2023
Main results expectedDecember 31, 2028
Study endsDecember 31, 2028
Registry record updatedOctober 4, 2024
Trial IDNCT06628102 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 50-80 with a chest CT showing a nodule of 6mm or larger and who have not smoked in the last 24 hours.

Probably not a fit

Patients who are too sick to provide a breath sample, pregnant, or have a recent respiratory infection may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to identify high-risk individuals for lung cancer who currently do not qualify for low-dose computed tomography (LDCT) screening. It will also establish a framework for managing patients with incidental pulmonary nodules (IPNs) through accurate interpretation of existing chest CT scans. Additionally, the study seeks to develop a minimally invasive test using breath samples and blood proteins to differentiate between cancerous and non-cancerous nodules. Participants will provide demographic and health-related information to aid in the assessment.

Why it matters

Potential benefit: If successful, this study could lead to earlier detection of lung cancer in patients who are currently overlooked, potentially saving lives.

How similar studies have gone: Other studies have shown promise in using similar approaches for lung cancer detection, but this specific methodology is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Age 50-80

* Able to consent
* Chest CT positive for nodule equal to or greater than 6mm
* No additional other cancer- (outside of lung cancer for group 1)
* Must be able to abstain from smoking tobacco for 24 hours prior to the breath test.

Exclusion Criteria:

* Too sick to provide a breath sample
* you have smoked in the last 24 hours
* You are pregnant
* You have been diagnosed with a respiratory infection in the last 3 months
* Unwilling to consent to the study

Where it's running

  • BC Cancer Research, part of the Provincial Health Authority
    Vancouver, British Columbia, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.