Improving dyskinesia in Parkinson's disease with interleaving stimulation
Official title: Interleaving Stimulation Improves Dyskinesia in Parkinson's Disease: Randomized, Double-blind, Controlled Trial
Run by Huashan Hospital · NCT06239454 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if a new type of brain stimulation can help reduce movement problems in people with Parkinson's disease better than the usual method.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 65 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Huashan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06239454 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 30-65 with a diagnosis of Parkinson's disease who have had the condition for at least 5 years and are not adequately controlled by medication.
✕Probably not a fit
Patients with major comorbidities, untreated significant depression, or those who have undergone previous neurosurgical procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of interleaving stimulation compared to empirical stimulation in managing dyskinesia in patients with Parkinson's disease. It is a prospective, randomized, double-blind, controlled trial involving 50 participants who will be assigned to either the interleaving stimulation modes group or the empirical stimulation modes group. The study will measure changes in dyskinesia scores, quality of life, and other relevant assessments over a 12-month period. Statistical analysis will be conducted to determine the differences in outcomes between the two groups.
Why it matters
Potential benefit: If successful, this approach could lead to improved management of dyskinesia symptoms in Parkinson's disease patients.
How similar studies have gone: While there have been studies on stimulation techniques in Parkinson's disease, the specific approach of interleaving stimulation is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1. Patients at the age of 30-65 years old. 2. Patients diagnosed as Parkinson's disease according to the UK Parkinson's Disease Society Brain Bank criteria. 3. Patients at Hoehn and Yahr stage 3 or lower in the on-state and stage 2 - 4 in the off-state. 4. The disease duration of 5 years or more. 5. Patients with deep levodopa-responsive Parkinson's disease, and are not adequately controlled by drug therapy. Exclusion Criteria: * major illness or medical comorbidities, depression that is untreated but judged to be clinically significant by an investigator, cochlear implants, cardiac pacemakers, needs for diathermy, anticoagulant therapy, previous neuro-surgical procedure or ablative therapy, frank dementia according to cognitive screening, drug or alcohol abuse, being a woman of child-bearing potential, having a positive pregnancy test, or presence of a terminal illness.
Where it's running
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Huashan Hospital
Shanghai, Shanghai, China Recruiting
Study contacts
- Study coordinator: Jian-Jun Wu, MD
- Email: jungliw@gmail.com
- Phone: 86-21-52888163
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.