Improving diagnosis of urinary tract infections in older patients
'Improving Urinary Tract Infection Diagnosis in Older Patients: Validation of a Biomarker Panel (UTI-GOLD)'
Leiden University Medical Center · NCT06610721
This study is testing a new way to diagnose urinary tract infections in older adults by looking at specific markers in their urine to see if it helps identify infections more accurately.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 264 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Leiden University Medical Center (other) |
| Locations | 1 site (Leiden, South Holland) |
| Trial ID | NCT06610721 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enhance the diagnosis of urinary tract infections (UTI) in individuals aged 65 and older by validating a panel of biomarkers. Researchers will determine the optimal cut-off values for biomarkers such as NGAL, IL-6, AZU, TIMP2, and CXCL9, assessing their sensitivity, specificity, and predictive values. Additionally, the study will evaluate the relationship between biomarker levels and clinical outcomes, including symptom duration and UTI recurrence. Participants will provide a urine sample and answer questions related to their symptoms.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 65 years or older who have a clinically suspected urinary tract infection.
Not a fit: Patients who are unable to provide a urine sample or have an indwelling catheter may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of UTIs in older patients, improving their treatment outcomes.
How similar studies have performed: Other studies have explored biomarker panels for UTI diagnosis, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Age 65 years or older * Clinically suspected UTI by treating physician * Sufficient understanding of the Dutch language Exclusion criteria: * Inability to obtain urine * Inability to provide written consent * The presence of an indwelling catheter
Where this trial is running
Leiden, South Holland
- Leiden university medical center (LUMC) — Leiden, South Holland, Netherlands (RECRUITING)
Study contacts
- Study coordinator: Nora El Moussaoui
- Email: n.el_moussaoui@lumc.nl
- Phone: 0031-0634531571
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Urinary Tract Infection, Urinary tract infection, Biomarkers